Details of the Target

General Information of Target

Target ID LDTP03809
Target Name Zinc finger protein 76 (ZNF76)
Gene Name ZNF76
Gene ID 7629
Synonyms
D6S229E; ZNF523; Zinc finger protein 76; Zinc finger protein 523
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESLGLHTVTLSDGTTAYVQQAVKGEKLLEGQVIQLEDGTTAYIHQVTVQKEALSFEDGQ
PVQLEDGSMAYIHRTPREGYDPSTLEAVQLEDGSTAYIHHPVAVPSESTILAVQTEVGLE
DLAAEDDEGFSADAVVALEQYASKVLHDSQIPRNGKGQQVGDRAFRCGYKGCGRLYTTAH
HLKVHERAHTGDRPYRCDFPSCGKAFATGYGLKSHVRTHTGEKPYKCPEELCSKAFKTSG
DLQKHVRTHTGERPFQCPFEGCGRSFTTSNIRKVHVRTHTGERPYTCPEPHCGRGFTSAT
NYKNHVRIHTGEKPYVCTVPGCGKRFTEYSSLYKHHVVHTHCKPYTCSTCGKTYRQTSTL
AMHKRSAHGELEATEESEQALYEQQQLEAASAAEESPPPKRPRIAYLSEVKEERDDIPAQ
VAMVTEEDGAPQVALITQDGAQQVSLSPEDLQALGSAISMVTQHGSTTLTIPSPDADLAT
SGTHTVTMVSADGTQTQPVTIITSGAVVAEDSSVASLRHQQVALLATANGTHIAVQLEEQ
QTLEEAINVATAAMQQGAVTLETTVSESGC
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
P36508
Ensemble ID
ENST00000339411.5
HGNC ID
HGNC:13149

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ABC1 SNV: p.E116V .
HCT116 SNV: p.T564A .
KYSE150 SNV: p.G293S .
LNCaP clone FGC SNV: p.L36I .
OV56 SNV: p.S269Y .
TOV21G Deletion: p.Q432RfsTer4 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0225  [1]
DBIA
 Probe Info  		C342(1.18)  LDD1492  [2]
HHS-465
 Probe Info  		K223(0.00); K226(0.00); Y225(0.00)  LDD2240  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C342(1.00)  LDD1507  [2]
 LDCM0226  AC11 HEK-293T C342(1.08)  LDD1509  [2]
 LDCM0276  AC17 HEK-293T C342(1.00)  LDD1515  [2]
 LDCM0278  AC19 HEK-293T C342(1.04)  LDD1517  [2]
 LDCM0285  AC25 HEK-293T C342(0.98)  LDD1524  [2]
 LDCM0287  AC27 HEK-293T C342(1.04)  LDD1526  [2]
 LDCM0290  AC3 HEK-293T C342(1.17)  LDD1529  [2]
 LDCM0294  AC33 HEK-293T C342(1.05)  LDD1533  [2]
 LDCM0296  AC35 HEK-293T C342(1.05)  LDD1535  [2]
 LDCM0303  AC41 HEK-293T C342(1.04)  LDD1542  [2]
 LDCM0305  AC43 HEK-293T C342(1.03)  LDD1544  [2]
 LDCM0311  AC49 HEK-293T C342(0.98)  LDD1550  [2]
 LDCM0314  AC51 HEK-293T C342(1.02)  LDD1553  [2]
 LDCM0320  AC57 HEK-293T C342(0.98)  LDD1559  [2]
 LDCM0322  AC59 HEK-293T C342(0.98)  LDD1561  [2]
 LDCM0356  AKOS034007680 HEK-293T C342(0.95)  LDD1570  [2]
 LDCM0369  CL100 HEK-293T C342(1.08)  LDD1573  [2]
 LDCM0373  CL104 HEK-293T C342(1.10)  LDD1577  [2]
 LDCM0377  CL108 HEK-293T C342(1.05)  LDD1581  [2]
 LDCM0382  CL112 HEK-293T C342(0.94)  LDD1586  [2]
 LDCM0386  CL116 HEK-293T C342(0.98)  LDD1590  [2]
 LDCM0391  CL120 HEK-293T C342(1.01)  LDD1595  [2]
 LDCM0395  CL124 HEK-293T C342(1.03)  LDD1599  [2]
 LDCM0399  CL128 HEK-293T C342(1.07)  LDD1603  [2]
 LDCM0403  CL16 HEK-293T C342(0.95)  LDD1607  [2]
 LDCM0404  CL17 HEK-293T C342(0.88)  LDD1608  [2]
 LDCM0406  CL19 HEK-293T C342(0.93)  LDD1610  [2]
 LDCM0416  CL28 HEK-293T C342(1.01)  LDD1620  [2]
 LDCM0417  CL29 HEK-293T C342(0.91)  LDD1621  [2]
 LDCM0420  CL31 HEK-293T C342(0.84)  LDD1624  [2]
 LDCM0429  CL4 HEK-293T C342(1.05)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C342(1.10)  LDD1634  [2]
 LDCM0431  CL41 HEK-293T C342(0.87)  LDD1635  [2]
 LDCM0433  CL43 HEK-293T C342(0.88)  LDD1637  [2]
 LDCM0440  CL5 HEK-293T C342(0.95)  LDD1644  [2]
 LDCM0443  CL52 HEK-293T C342(1.14)  LDD1646  [2]
 LDCM0444  CL53 HEK-293T C342(0.87)  LDD1647  [2]
 LDCM0446  CL55 HEK-293T C342(0.97)  LDD1649  [2]
 LDCM0456  CL64 HEK-293T C342(0.97)  LDD1659  [2]
 LDCM0457  CL65 HEK-293T C342(1.08)  LDD1660  [2]
 LDCM0459  CL67 HEK-293T C342(0.92)  LDD1662  [2]
 LDCM0462  CL7 HEK-293T C342(0.98)  LDD1665  [2]
 LDCM0469  CL76 HEK-293T C342(1.08)  LDD1672  [2]
 LDCM0470  CL77 HEK-293T C342(0.91)  LDD1673  [2]
 LDCM0472  CL79 HEK-293T C342(0.89)  LDD1675  [2]
 LDCM0482  CL88 HEK-293T C342(1.11)  LDD1685  [2]
 LDCM0483  CL89 HEK-293T C342(1.11)  LDD1686  [2]
 LDCM0486  CL91 HEK-293T C342(0.95)  LDD1689  [2]
 LDCM0022  KB02 HEK-293T C342(1.18)  LDD1492  [2]
 LDCM0023  KB03 HEK-293T C342(1.04)  LDD1497  [2]
 LDCM0024  KB05 HEK-293T C342(1.01)  LDD1502  [2]
 LDCM0109  NEM HeLa N.A.  LDD0225  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adenine nucleotide translocase lysine N-methyltransferase (ANTKMT) ANT/ATPSC lysine N-methyltransferase family Q9BQD7
Exosome complex component CSL4 (EXOSC1) CSL4 family Q9Y3B2
Kappa-casein (CSN3) Kappa-casein family P07498
Hydroperoxide isomerase ALOXE3 (ALOXE3) Lipoxygenase family Q9BYJ1
Trimethylguanosine synthase (TGS1) Trimethylguanosine synthase family Q96RS0
Ubiquitin carboxyl-terminal hydrolase 7 (USP7) Peptidase C19 family Q93009
Mitochondrial-processing peptidase subunit alpha (PMPCA) Peptidase M16 family Q10713
Cytosol aminopeptidase (LAP3) Peptidase M17 family P28838
Acetyl-CoA acetyltransferase, cytosolic (ACAT2) Thiolase family Q9BWD1
Fibronectin type III and SPRY domain-containing protein 2 (FSD2) . A1L4K1
Nuclear receptor-interacting protein 2 (NRIP2) . Q9BQI9
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATP synthase subunit O, mitochondrial (ATP5PO) ATPase delta chain family P48047
Importin subunit alpha-4 (KPNA3) Importin alpha family O00505
Mitochondrial proton/calcium exchanger protein (LETM1) LETM1 family O95202
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Transcription factor
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9
Zinc finger protein 526 (ZNF526) Krueppel C2H2-type zinc-finger protein family Q8TF50
Zinc finger protein 623 (ZNF623) Krueppel C2H2-type zinc-finger protein family O75123
Zinc finger protein SNAI2 (SNAI2) Snail C2H2-type zinc-finger protein family O43623
Krueppel-like factor 15 (KLF15) Sp1 C2H2-type zinc-finger protein family Q9UIH9
Golgin-45 (BLZF1) . Q9H2G9
LIM/homeobox protein Lhx4 (LHX4) . Q969G2
LIM/homeobox protein Lhx6 (LHX6) . Q9UPM6
Pogo transposable element with ZNF domain (POGZ) . Q7Z3K3
Zinc finger protein 420 (ZNF420) . Q8TAQ5
Immunoglobulin
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) CEA family P40199
Fc receptor-like protein 4 (FCRL4) . Q96PJ5
Other
Click To Hide/Show 38 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Large ribosomal subunit protein bL12m (MRPL12) Bacterial ribosomal protein bL12 family P52815
cAMP-dependent protein kinase type I-beta regulatory subunit (PRKAR1B) CAMP-dependent kinase regulatory chain family P31321
Centrosomal protein of 76 kDa (CEP76) CEP76 family Q8TAP6
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Small ribosomal subunit protein eS21 (RPS21) Eukaryotic ribosomal protein eS21 family P63220
Protein FAM228A (FAM228A) FAM228 family Q86W67
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
GRB2-related adapter protein-like (GRAPL) GRB2/sem-5/DRK family Q8TC17
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin, type II cytoskeletal 75 (KRT75) Intermediate filament family O95678
Protein lin-54 homolog (LIN54) Lin-54 family Q6MZP7
Methyl-CpG-binding domain protein 3-like 1 (MBD3L1) MBD3L family Q8WWY6
Microfibrillar-associated protein 1 (MFAP1) MFAP1 family P55081
Mitochondrial fission regulator 1-like (MTFR1L) MTFR1 family Q9H019
SLAIN motif-containing protein 1 (SLAIN1) SLAIN motif-containing family Q8ND83
Sperm protein associated with the nucleus on the X chromosome N3 (SPANXN3) SPAN-X family Q5MJ09
Stathmin-3 (STMN3) Stathmin family Q9NZ72
Protein TASOR 2 (TASOR2) TASOR family Q5VWN6
Tektin-5 (TEKT5) Tektin family Q96M29
Troponin I, slow skeletal muscle (TNNI1) Troponin I family P19237
Vexin (VXN) Vexin family Q8TAG6
WD repeat domain-containing protein 83 (WDR83) WD repeat MORG1 family Q9BRX9
Ankyrin repeat domain-containing protein 37 (ANKRD37) . Q7Z713
BTB/POZ domain-containing protein KCTD9 (KCTD9) . Q7L273
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
Fibronectin type III domain-containing protein 8 (FNDC8) . Q8TC99
Four and a half LIM domains protein 2 (FHL2) . Q14192
Melanoma-associated antigen 6 (MAGEA6) . P43360
MORN repeat-containing protein 3 (MORN3) . Q6PF18
Myosin regulatory light chain 10 (MYL10) . Q9BUA6
Protein lin-37 homolog (LIN37) . Q96GY3
Rhombotin-1 (LMO1) . P25800
Sperm-associated microtubule inner protein 10 (SPMIP10) . Q6ZNM6
Spermatogenesis-associated protein 8 (SPATA8) . Q6RVD6
TBC1 domain family member 22B (TBC1D22B) . Q9NU19
Uncharacterized protein C10orf55 (C10orf55) . Q5SWW7
Uncharacterized protein C3orf36 (C3orf36) . Q3SXR2
Zinc finger C4H2 domain-containing protein (ZC4H2) . Q9NQZ6

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010