Details of the Target

General Information of Target

Target ID LDTP03666
Target Name Lymphocyte-specific protein 1 (LSP1)
Gene Name LSP1
Gene ID 4046
Synonyms
WP34; Lymphocyte-specific protein 1; 47 kDa actin-binding protein; 52 kDa phosphoprotein; pp52; Lymphocyte-specific antigen WP34
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEASSDPGAEEREELLGPTAQWSVEDEEEAVHEQCQHERDRQLQAQDEEGGGHVPERPK
QEMLLSLKPSEAPELDEDEGFGDWSQRPEQRQQHEGAQGALDSGEPPQCRSPEGEQEDRP
GLHAYEKEDSDEVHLEELSLSKEGPGPEDTVQDNLGAAGAEEEQEEHQKCQQPRTPSPLV
LEGTIEQSSPPLSPTTKLIDRTESLNRSIEKSNSVKKSQPDLPISKIDQWLEQYTQAIET
AGRTPKLARQASIELPSMAVASTKSRWETGEVQAQSAAKTPSCKDIVAGDMSKKSLWEQK
GGSKTSSTIKSTPSGKRYKFVATGHGKYEKVLVEGGPAP
Target Bioclass
Other
Subcellular location
Cell membrane
Function May play a role in mediating neutrophil activation and chemotaxis.
Uniprot ID
P33241
Ensemble ID
ENST00000311604.8
HGNC ID
HGNC:6707

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAKI1 SNV: p.L65H .
K562 SNV: p.G52S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K226(20.00)  LDD2218  [1]
IA-alkyne
 Probe Info  		C283(1.34); C36(1.18)  LDD0304  [2]
DBIA
 Probe Info  		C47(1.96)  LDD3339  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C283(1.24); C170(1.68)  LDD2187  [4]
 LDCM0572  Fragment10 Ramos C283(2.16); C109(3.62); C170(0.87)  LDD2189  [4]
 LDCM0573  Fragment11 Ramos C36(20.00); C170(1.14)  LDD2190  [4]
 LDCM0574  Fragment12 Ramos C283(1.02); C109(0.53); C170(0.38)  LDD2191  [4]
 LDCM0575  Fragment13 Ramos C283(1.62); C109(1.23); C170(0.96)  LDD2192  [4]
 LDCM0576  Fragment14 Ramos C283(0.73); C109(0.30); C36(0.16); C170(0.53)  LDD2193  [4]
 LDCM0579  Fragment20 Ramos C283(1.04); C109(1.03); C170(0.35)  LDD2194  [4]
 LDCM0580  Fragment21 Ramos C283(1.43); C170(0.96)  LDD2195  [4]
 LDCM0582  Fragment23 Ramos C283(2.03); C170(1.22)  LDD2196  [4]
 LDCM0578  Fragment27 Ramos C283(1.23); C170(1.11)  LDD2197  [4]
 LDCM0586  Fragment28 Ramos C283(0.82)  LDD2198  [4]
 LDCM0588  Fragment30 Ramos C283(2.01); C170(1.17)  LDD2199  [4]
 LDCM0589  Fragment31 Ramos C283(1.72); C170(0.71)  LDD2200  [4]
 LDCM0590  Fragment32 Ramos C283(3.19); C170(1.92)  LDD2201  [4]
 LDCM0468  Fragment33 Ramos C283(2.99); C109(2.34); C170(1.13)  LDD2202  [4]
 LDCM0596  Fragment38 Ramos C283(0.71); C109(0.45); C170(0.67)  LDD2203  [4]
 LDCM0566  Fragment4 Ramos C283(0.73); C109(1.45); C170(0.88)  LDD2184  [4]
 LDCM0610  Fragment52 Ramos C283(1.86); C170(9.01)  LDD2204  [4]
 LDCM0614  Fragment56 Ramos C283(1.94); C170(1.21)  LDD2205  [4]
 LDCM0569  Fragment7 Ramos C283(0.79); C109(1.61); C36(0.45); C170(1.20)  LDD2186  [4]
 LDCM0571  Fragment9 Ramos C283(1.36); C170(0.58)  LDD2188  [4]
 LDCM0022  KB02 Ramos C283(1.39); C109(2.80); C170(1.32)  LDD2182  [4]
 LDCM0023  KB03 Ramos C283(0.81); C109(1.16); C36(0.62); C170(0.91)  LDD2183  [4]
 LDCM0024  KB05 NALM-6 C47(1.96)  LDD3339  [3]
 LDCM0131  RA190 MM1.R C283(1.34); C36(1.18)  LDD0304  [2]

References

1 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
2 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578