Details of the Target

General Information of Target

Target ID LDTP03639
Target Name Neuronal acetylcholine receptor subunit alpha-3 (CHRNA3)
Gene Name CHRNA3
Gene ID 1136
Synonyms
NACHRA3; Neuronal acetylcholine receptor subunit alpha-3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGSGPLSLPLALSPPRLLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPV
IIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPD
IVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSW
SYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRL
PLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLV
IPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPT
SNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLT
RSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFL
WVFTLVCILGTAGLFLQPLMAREDA
Target Bioclass
Transporter and channel
Family
Ligand-gated ion channel (TC 1.A.9) family, Acetylcholine receptor (TC 1.A.9.1) subfamily, Alpha-3/CHRNA3 sub-subfamily
Subcellular location
Postsynaptic cell membrane
Function After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Uniprot ID
P32297
Ensemble ID
ENST00000326828.6
HGNC ID
HGNC:1957
ChEMBL ID
CHEMBL3068

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		6.06  LDD0318  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 14 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Amantadine Small molecular drug DB00915
Bupropion Small molecular drug DB01156
Butabarbital Small molecular drug DB00237
Cisatracurium Small molecular drug DB00565
Dextromethorphan Small molecular drug DB00514
Ethanol Small molecular drug DB00898
Fluoxetine Small molecular drug DB00472
Levacetylmethadol Small molecular drug DB01227
Levamisole Small molecular drug DB00848
Methadone Small molecular drug DB00333
Nicotine Small molecular drug DB00184
Pentolinium Small molecular drug DB01090
Succinylcholine Small molecular drug DB00202
Varenicline Small molecular drug DB01273
Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cytisine Small molecular drug DB09028
Epibatidine Small molecular drug DB07720
Gantacurium . DB05710

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580