Details of the Target

General Information of Target

Target ID LDTP03603
Target Name Sodium- and chloride-dependent taurine transporter (SLC6A6)
Gene Name SLC6A6
Gene ID 6533
Synonyms
Sodium- and chloride-dependent taurine transporter; Solute carrier family 6 member 6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATKEKLQCLKDFHKDILKPSPGKSPGTRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVG
LGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLF
SGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWAHCNHSWNTPHCMEDTMRKNK
SVWITISSTNFTSPVIEFWERNVLSLSPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVR
STGKVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKFYLYPDITRLEDPQVWIDAGTQIFF
SYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGVDIA
DVAESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPS
FLRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIA
WIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIFSLVKYVPLTYNKTYVYPN
WAIGLGWSLALSSMLCVPLVIVIRLCQTEGPFLVRVKYLLTPREPNRWAVEREGATPYNS
RTVMNGALVKPTHIIVETMM
Target Bioclass
Transporter and channel
Family
Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A6 subfamily
Subcellular location
Cell membrane
Function
Mediates sodium- and chloride-dependent transport of taurine. Mediates transport of beta-alanine. Can also mediate transport of hypotaurine and gamma-aminobutyric acid (GABA).; Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake.
Uniprot ID
P31641
Ensemble ID
ENST00000621751.4
HGNC ID
HGNC:11052
ChEMBL ID
CHEMBL5762

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.A343T .
COLO678 Deletion: p.F58_V59del .
HCT15 Deletion: p.F392LfsTer31 .
JURLMK1 SNV: p.F88L .
NCIH1993 SNV: p.G124S .
NCIH2291 SNV: p.G451R .
PC14 SNV: p.D32G .
REH SNV: p.Y104H .
RL952 SNV: p.G91S .
SKOV3 Deletion: p.F392LfsTer31 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K577(5.02); K6(10.00)  LDD0277  [1]
IA-alkyne
 Probe Info  		C71(1.79)  LDD2182  [2]
TFBX
 Probe Info  		N.A.  LDD0027  [3]
IPM
 Probe Info  		N.A.  LDD0147  [3]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0139  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C9(1.79); C71(0.96)  LDD2187  [2]
 LDCM0572  Fragment10 Ramos C9(0.55); C71(1.10)  LDD2189  [2]
 LDCM0573  Fragment11 Ramos C71(0.11)  LDD2190  [2]
 LDCM0574  Fragment12 Ramos C9(6.14)  LDD2191  [2]
 LDCM0575  Fragment13 Ramos C9(1.07); C71(0.82)  LDD2192  [2]
 LDCM0576  Fragment14 Ramos C9(3.21); C71(6.09)  LDD2193  [2]
 LDCM0580  Fragment21 Ramos C9(1.17); C71(0.89)  LDD2195  [2]
 LDCM0582  Fragment23 Ramos C9(1.35); C71(0.75)  LDD2196  [2]
 LDCM0578  Fragment27 Ramos C9(0.69); C71(0.68)  LDD2197  [2]
 LDCM0586  Fragment28 Ramos C9(0.91); C71(0.87)  LDD2198  [2]
 LDCM0588  Fragment30 Ramos C9(0.98); C71(0.96)  LDD2199  [2]
 LDCM0589  Fragment31 Ramos C9(1.29); C71(0.86)  LDD2200  [2]
 LDCM0590  Fragment32 Ramos C71(1.42)  LDD2201  [2]
 LDCM0468  Fragment33 Ramos C9(1.14); C71(0.93)  LDD2202  [2]
 LDCM0596  Fragment38 Ramos C9(1.31); C71(2.04)  LDD2203  [2]
 LDCM0566  Fragment4 Ramos C71(1.91)  LDD2184  [2]
 LDCM0610  Fragment52 Ramos C9(3.99); C71(1.13)  LDD2204  [2]
 LDCM0614  Fragment56 Ramos C9(1.58); C71(0.82)  LDD2205  [2]
 LDCM0569  Fragment7 Ramos C9(7.50); C71(1.42)  LDD2186  [2]
 LDCM0022  KB02 Ramos C71(1.79)  LDD2182  [2]
 LDCM0023  KB03 MDA-MB-231 C71(20.02)  LDD1701  [5]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Taurine Small molecular drug DB01956

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761