Details of the Target

General Information of Target

Target ID LDTP03376
Target Name Interleukin-3 receptor subunit alpha (IL3RA)
Gene Name IL3RA
Gene ID 3563
Synonyms
IL3R; Interleukin-3 receptor subunit alpha; IL-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha; IL-3RA; CD antigen CD123
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVLLWLTLLLIALPCLLQTKEDPNPPITNLRMKAKAQQLTWDLNRNVTDIECVKDADYSM
PAVNNSYCQFGAISLCEVTNYTVRVANPPFSTWILFPENSGKPWAGAENLTCWIHDVDFL
SCSWAVGPGAPADVQYDLYLNVANRRQQYECLHYKTDAQGTRIGCRFDDISRLSSGSQSS
HILVRGRSAAFGIPCTDKFVVFSQIEILTPPNMTAKCNKTHSFMHWKMRSHFNRKFRYEL
QIQKRMQPVITEQVRDRTSFQLLNPGTYTVQIRARERVYEFLSAWSTPQRFECDQEEGAN
TRAWRTSLLIALGTLLALVCVFVICRRYLVMQRLFPRIPHMKDPIGDSFQNDKLVVWEAG
KAGLEECLVTEVQVVQKT
Target Type
Successful
Target Bioclass
Cytokine and receptor
Family
Type I cytokine receptor family, Type 5 subfamily
Subcellular location
Membrane
Function
Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program.
TTD ID
T71377
Uniprot ID
P26951
DrugMap ID
TTENHJ0
Ensemble ID
ENST00000331035.10
HGNC ID
HGNC:6012
ChEMBL ID
CHEMBL3712987

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A172 SNV: p.R31T .
CAL51 SNV: p.I338T .
KASUMI2 SNV: p.V270A .
RL952 Deletion: p.A132RfsTer9 .
U937 Insertion: p.D197RfsTer2 .
YSCCC SNV: p.Q350E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C151(1.08)  LDD1573  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0369  CL100 HEK-293T C151(1.08)  LDD1573  [1]
 LDCM0373  CL104 HEK-293T C151(0.78)  LDD1577  [1]
 LDCM0377  CL108 HEK-293T C151(0.72)  LDD1581  [1]
 LDCM0382  CL112 HEK-293T C151(0.80)  LDD1586  [1]
 LDCM0386  CL116 HEK-293T C151(0.86)  LDD1590  [1]
 LDCM0391  CL120 HEK-293T C151(0.84)  LDD1595  [1]
 LDCM0395  CL124 HEK-293T C151(0.47)  LDD1599  [1]
 LDCM0399  CL128 HEK-293T C151(0.94)  LDD1603  [1]
 LDCM0403  CL16 HEK-293T C151(0.97)  LDD1607  [1]
 LDCM0416  CL28 HEK-293T C151(0.81)  LDD1620  [1]
 LDCM0429  CL4 HEK-293T C151(1.28)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C151(1.20)  LDD1634  [1]
 LDCM0443  CL52 HEK-293T C151(0.97)  LDD1646  [1]
 LDCM0456  CL64 HEK-293T C151(0.93)  LDD1659  [1]
 LDCM0469  CL76 HEK-293T C151(0.98)  LDD1672  [1]
 LDCM0482  CL88 HEK-293T C151(1.24)  LDD1685  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402