Details of the Target

General Information of Target

Target ID LDTP03373
Target Name CD27 antigen (CD27)
Gene Name CD27
Gene ID 939
Synonyms
TNFRSF7; CD27 antigen; CD27L receptor; T-cell activation antigen CD27; T14; Tumor necrosis factor receptor superfamily member 7; CD antigen CD27
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MARPHPWWLCVLGTLVGLSATPAPKSCPERHYWAQGKLCCQMCEPGTFLVKDCDQHRKAA
QCDPCIPGVSFSPDHHTRPHCESCRHCNSGLLVRNCTITANAECACRNGWQCRDKECTEC
DPLPNPSLTARSSQALSPHPQPTHLPYVSEMLEARTAGHMQTLADFRQLPARTLSTHWPP
QRSLCSSDFIRILVIFSGMFLVFTLAGALFLHQRRKYRSNKGESPVEPAEPCHYSCPREE
EGSTIPIQEDYRKPEPACSP
Target Type
Clinical trial
Target Bioclass
Cytokine and receptor
Subcellular location
Membrane
Function Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.
TTD ID
T85554
Uniprot ID
P26842
DrugMap ID
TTDO1MV
Ensemble ID
ENST00000266557.4
HGNC ID
HGNC:11922
ChEMBL ID
CHEMBL3713333

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C258(2.08); C185(1.71)  LDD3339  [1]
IA-alkyne
 Probe Info  		C258(0.69); C185(2.17)  LDD2182  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C258(1.98); C185(2.56)  LDD2187  [2]
 LDCM0572  Fragment10 Ramos C258(1.29)  LDD2189  [2]
 LDCM0573  Fragment11 Ramos C258(20.00); C185(0.05)  LDD2190  [2]
 LDCM0574  Fragment12 Ramos C258(1.16); C185(4.05)  LDD2191  [2]
 LDCM0575  Fragment13 Ramos C258(1.35); C185(1.10)  LDD2192  [2]
 LDCM0576  Fragment14 Ramos C258(0.70); C185(6.04)  LDD2193  [2]
 LDCM0579  Fragment20 Ramos C258(0.83); C185(5.87)  LDD2194  [2]
 LDCM0580  Fragment21 Ramos C258(1.32); C185(1.17)  LDD2195  [2]
 LDCM0582  Fragment23 Ramos C258(1.69); C185(1.38)  LDD2196  [2]
 LDCM0578  Fragment27 Ramos C258(1.30); C185(0.81)  LDD2197  [2]
 LDCM0586  Fragment28 Ramos C258(0.78); C185(0.78)  LDD2198  [2]
 LDCM0588  Fragment30 Ramos C258(1.49); C185(1.41)  LDD2199  [2]
 LDCM0589  Fragment31 Ramos C258(1.32); C185(1.78)  LDD2200  [2]
 LDCM0590  Fragment32 Ramos C258(1.46)  LDD2201  [2]
 LDCM0468  Fragment33 Ramos C258(1.55); C185(1.55)  LDD2202  [2]
 LDCM0596  Fragment38 Ramos C258(1.05); C185(2.49)  LDD2203  [2]
 LDCM0566  Fragment4 Ramos C258(0.89); C185(3.88)  LDD2184  [2]
 LDCM0610  Fragment52 Ramos C258(2.50); C185(1.85)  LDD2204  [2]
 LDCM0614  Fragment56 Ramos C258(1.65); C185(0.95)  LDD2205  [2]
 LDCM0569  Fragment7 Ramos C258(0.87); C185(3.60)  LDD2186  [2]
 LDCM0571  Fragment9 Ramos C258(1.13)  LDD2188  [2]
 LDCM0022  KB02 Ramos C258(0.69); C185(2.17)  LDD2182  [2]
 LDCM0023  KB03 Ramos C258(0.59); C185(2.88)  LDD2183  [2]
 LDCM0024  KB05 NALM-6 C258(2.08); C185(1.71)  LDD3339  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578