Details of the Target
General Information of Target
| Target ID | LDTP03349 | |||||
|---|---|---|---|---|---|---|
| Target Name | Catenin alpha-2 (CTNNA2) | |||||
| Gene Name | CTNNA2 | |||||
| Gene ID | 1496 | |||||
| Synonyms |
CAPR; Catenin alpha-2; Alpha N-catenin; Alpha-catenin-related protein |
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| 3D Structure | ||||||
| Sequence |
MTSATSPIILKWDPKSLEIRTLTVERLLEPLVTQVTTLVNTSNKGPSGKKKGRSKKAHVL
AASVEQATQNFLEKGEQIAKESQDLKEELVAAVEDVRKQGETMRIASSEFADDPCSSVKR GTMVRAARALLSAVTRLLILADMADVMRLLSHLKIVEEALEAVKNATNEQDLANRFKEFG KEMVKLNYVAARRQQELKDPHCRDEMAAARGALKKNATMLYTASQAFLRHPDVAATRANR DYVFKQVQEAIAGISNAAQATSPTDEAKGHTGIGELAAALNEFDNKIILDPMTFSEARFR PSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMNNTGRKEKGD PLNIAIDKMTKKTRDLRRQLRKAVMDHISDSFLETNVPLLVLIEAAKSGNEKEVKEYAQV FREHANKLVEVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQD NMDVFKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTA GAIRGRAARVIHIINAEMENYEAGVYTEKVLEATKLLSETVMPRFAEQVEVAIEALSANV PQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDD QLIAGQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCM IMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSRMDKLARAVADQCPDSACKQDLLAYLQ RIALYCHQLNICSKVKAEVQNLGGELIVSGTGVQSTFTTFYEVDCDVIDGGRASQLSTHL PTCAEGAPIGSGSSDSSMLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQKVYGTAAVN SPVVSWKMKAPEKKPLVKREKPEEFQTRVRRGSQKKHISPVQALSEFKAMDSF |
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| Target Bioclass |
Other
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| Family |
Vinculin/alpha-catenin family
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| Subcellular location |
Cell membrane
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| Function |
May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Required for proper regulation of cortical neuronal migration and neurite growth. It acts as a negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization. It thereby suppresses excessive actin branching which would impair neurite growth and stability. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| CAOV3 | SNV: p.P603A | DBIA Probe Info | |||
| DU145 | SNV: p.I553N | DBIA Probe Info | |||
| EFO27 | SNV: p.T567N | DBIA Probe Info | |||
| EOL1 | SNV: p.A418P | DBIA Probe Info | |||
| HCT15 | SNV: p.E65D | DBIA Probe Info | |||
| HEC1 | SNV: p.G409V | DBIA Probe Info | |||
| HT115 | SNV: p.V893A | DBIA Probe Info | |||
| IM95 | SNV: p.I526V | DBIA Probe Info | |||
| K562 | SNV: p.Q170Ter | . | |||
| KMS11 | SNV: p.T37A; p.V332M | DBIA Probe Info | |||
| KYSE30 | SNV: p.V823A | DBIA Probe Info | |||
| MCC26 | SNV: p.A943V | DBIA Probe Info | |||
| MEWO | SNV: p.G211E | DBIA Probe Info | |||
| NB1 | SNV: p.S864L | DBIA Probe Info | |||
| NCIH1048 | SNV: p.A226T | DBIA Probe Info | |||
| NCIH446 | SNV: p.R300L | DBIA Probe Info | |||
| NCIH661 | SNV: p.A592D | . | |||
| NCIN87 | Deletion: p.H552PfsTer30 | DBIA Probe Info | |||
| ONS76 | SNV: p.F71S | DBIA Probe Info | |||
| RL952 | SNV: p.K680E | DBIA Probe Info | |||
| RPMI7951 | SNV: p.E724K | DBIA Probe Info | |||
| SW1271 | Substitution: p.A465E | DBIA Probe Info | |||
| TE11 | SNV: p.S793I; p.S809P | DBIA Probe Info | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
Probe 1 Probe Info |
 |
Y884(97.05) | LDD3495 | [1] | |
|
DBIA Probe Info |
 |
C356(1.31) | LDD3311 | [2] | |
|
BTD Probe Info |
 |
C335(0.83) | LDD2089 | [3] | |
|
AHL-Pu-1 Probe Info |
 |
C719(2.18) | LDD0170 | [4] | |
|
HHS-475 Probe Info |
 |
Y778(0.62) | LDD0264 | [5] | |
|
5E-2FA Probe Info |
 |
N.A. | LDD2235 | [6] | |
|
m-APA Probe Info |
 |
N.A. | LDD2231 | [6] | |
|
IA-alkyne Probe Info |
 |
N.A. | LDD0175 | [7] | |
|
NAIA_5 Probe Info |
 |
C335(0.00); C322(0.00); C792(0.00); C786(0.00) | LDD2223 | [8] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0537 | 2-Cyano-N,N-dimethylacetamide | MDA-MB-231 | C335(0.88) | LDD2130 | [3] |
| LDCM0025 | 4SU-RNA | DM93 | C719(2.18) | LDD0170 | [4] |
| LDCM0026 | 4SU-RNA+native RNA | DM93 | C719(5.30) | LDD0171 | [4] |
| LDCM0116 | HHS-0101 | DM93 | Y778(0.62) | LDD0264 | [5] |
| LDCM0117 | HHS-0201 | DM93 | Y778(0.44) | LDD0265 | [5] |
| LDCM0118 | HHS-0301 | DM93 | Y778(0.74) | LDD0266 | [5] |
| LDCM0119 | HHS-0401 | DM93 | Y778(0.94) | LDD0267 | [5] |
| LDCM0120 | HHS-0701 | DM93 | Y778(1.17) | LDD0268 | [5] |
| LDCM0022 | KB02 | 22RV1 | C356(1.11); C753(1.21) | LDD2243 | [2] |
| LDCM0023 | KB03 | 22RV1 | C356(1.59); C753(1.68) | LDD2660 | [2] |
| LDCM0024 | KB05 | G361 | C356(1.31) | LDD3311 | [2] |
| LDCM0496 | Nucleophilic fragment 11a | MDA-MB-231 | C335(0.83) | LDD2089 | [3] |
The Interaction Atlas With This Target
References