Details of the Target

General Information of Target

Target ID LDTP03260
Target Name Peripherin-2 (PRPH2)
Gene Name PRPH2
Gene ID 5961
Synonyms
PRPH; RDS; TSPAN22; Peripherin-2; Retinal degeneration slow protein; Tetraspanin-22; Tspan-22
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALLKVKFDQKKRVKLAQGLWLMNWFSVLAGIIIFSLGLFLKIELRKRSDVMNNSESHFV
PNSLIGMGVLSCVFNSLAGKICYDALDPAKYARWKPWLKPYLAICVLFNIILFLVALCCF
LLRGSLENTLGQGLKNGMKYYRDTDTPGRCFMKKTIDMLQIEFKCCGNNGFRDWFEIQWI
SNRYLDFSSKEVKDRIKSNVDGRYLVDGVPFSCCNPSSPRPCIQYQITNNSAHYSYDHQT
EELNLWVRGCRAALLSYYSSLMNSMGVVTLLIWLFEVTITIGLRYLQTSLDGVSNPEESE
SESQGWLLERSVPETWKAFLESVKKLGKGNQVEAEGADAGQAPEAG
Target Bioclass
Transporter and channel
Family
PRPH2/ROM1 family
Subcellular location
Membrane
Function
Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure. Required for the maintenance of retinal outer nuclear layer thickness. Required for the correct development and organization of the photoreceptor inner segment.
Uniprot ID
P23942
Ensemble ID
ENST00000230381.7
HGNC ID
HGNC:9942

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C144(2.34); C324(3.57)  LDD3340  [1]
IA-alkyne
 Probe Info  		C82(0.70)  LDD2182  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C82(0.83)  LDD2187  [2]
 LDCM0572  Fragment10 Ramos C82(0.61)  LDD2189  [2]
 LDCM0573  Fragment11 Ramos C82(0.23)  LDD2190  [2]
 LDCM0574  Fragment12 Ramos C82(1.23)  LDD2191  [2]
 LDCM0575  Fragment13 Ramos C82(0.80)  LDD2192  [2]
 LDCM0576  Fragment14 Ramos C82(2.33)  LDD2193  [2]
 LDCM0579  Fragment20 Ramos C82(1.31)  LDD2194  [2]
 LDCM0580  Fragment21 Ramos C82(0.71)  LDD2195  [2]
 LDCM0582  Fragment23 Ramos C82(0.72)  LDD2196  [2]
 LDCM0578  Fragment27 Ramos C82(0.69)  LDD2197  [2]
 LDCM0586  Fragment28 Ramos C82(0.25)  LDD2198  [2]
 LDCM0588  Fragment30 Ramos C82(0.99)  LDD2199  [2]
 LDCM0589  Fragment31 Ramos C82(1.07)  LDD2200  [2]
 LDCM0590  Fragment32 Ramos C82(0.96)  LDD2201  [2]
 LDCM0468  Fragment33 Ramos C82(1.22)  LDD2202  [2]
 LDCM0596  Fragment38 Ramos C82(1.77)  LDD2203  [2]
 LDCM0566  Fragment4 Ramos C82(0.85)  LDD2184  [2]
 LDCM0610  Fragment52 Ramos C82(0.89)  LDD2204  [2]
 LDCM0614  Fragment56 Ramos C82(1.01)  LDD2205  [2]
 LDCM0569  Fragment7 Ramos C82(1.22)  LDD2186  [2]
 LDCM0571  Fragment9 Ramos C82(0.98)  LDD2188  [2]
 LDCM0022  KB02 Ramos C82(0.70)  LDD2182  [2]
 LDCM0023  KB03 Ramos C82(1.99)  LDD2183  [2]
 LDCM0024  KB05 NB1 C144(2.34); C324(3.57)  LDD3340  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578