Details of the Target

General Information of Target

Target ID LDTP03215
Target Name Carbonic anhydrase 6 (CA6)
Gene Name CA6
Gene ID 765
Synonyms
Carbonic anhydrase 6; EC 4.2.1.1; Carbonate dehydratase VI; Carbonic anhydrase VI; CA-VI; Salivary carbonic anhydrase; Secreted carbonic anhydrase
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MRALVLLLSLFLLGGQAQHVSDWTYSEGALDEAHWPQHYPACGGQRQSPINLQRTKVRYN
PSLKGLNMTGYETQAGEFPMVNNGHTVQISLPSTMRMTVADGTVYIAQQMHFHWGGASSE
ISGSEHTVDGIRHVIEIHIVHYNSKYKSYDIAQDAPDGLAVLAAFVEVKNYPENTYYSNF
ISHLANIKYPGQRTTLTGLDVQDMLPRNLQHYYTYHGSLTTPPCTENVHWFVLADFVKLS
RTQVWKLENSLLDHRNKTIHNDYRRTQPLNHRVVESNFPNQEYTLGSEFQFYLHKIEEIL
DYLRRALN
Target Type
Successful
Target Bioclass
Enzyme
Family
Alpha-carbonic anhydrase family
Subcellular location
Secreted
Function Reversible hydration of carbon dioxide. Its role in saliva is unknown.
TTD ID
T06569
Uniprot ID
P23280
DrugMap ID
TTCFSPE
Ensemble ID
ENST00000377436.6
HGNC ID
HGNC:1380
ChEMBL ID
CHEMBL3025

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MFE319 SNV: p.Y292C .
SKMEL3 SNV: p.A155V .
SUPT1 SNV: p.Y59Ter .
ZR751 SNV: p.H141Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CY4
 Probe Info  		N.A.  LDD0247  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 6 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Benzthiazide Small molecular drug DB00562
Cyclothiazide Small molecular drug DB00606
Mafenide Small molecular drug DB06795
Salicyclic Acid Small molecular drug D07HBX
Sulfamylon Small molecular drug D0K1QD
Zonisamide Small molecular drug DB00909
Phase 3
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Curcumin Small molecular drug D07SDQ
Paraben . D0A8JP
Phase 2
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Sar566658 Antibody D43GZX
Coumate Small molecular drug D0Y6OA
Investigative
Click To Hide/Show 40 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
2,4-disulfamyltrifluoromethylaniline Small molecular drug D0M3PO
2-amino-benzenesulfonamide Small molecular drug D0OI1H
2-hydrazinylbenzenesulfonamide Small molecular drug D0G0FJ
4-(2-aminopyrimidin-4-ylamino)Benzenesulfonamide Small molecular drug D0TY8X
4-(Hydroxymethyl)Benzenesulfonamide Small molecular drug D05XZM
4-amino-3-chloro-benzenesulfonamide Small molecular drug D0YU8J
4-amino-6-chlorobenzene-1,3-disulfonamide Small molecular drug D0Z1HY
4-amino-n-(4-sulfamoylbenzyl)Benzenesulfonamide Small molecular drug D0X6IE
4-cyanophenol Small molecular drug D00IUB
4-hydrazino-benzenesulfonamide Small molecular drug D0NN3Q
6-(Aminomethyl)-2h-chromen-2-one Small molecular drug D0N1AW
6-(Hydroxymethyl)-2h-chromen-2-one Small molecular drug D0L5TZ
7-butoxy-2h-chromen-2-one Small molecular drug D0LU4S
7-propoxy-2h-chromen-2-one Small molecular drug D0OT5L
Benzolamide Small molecular drug D0E8CC
Carzenide Small molecular drug D09PWX
Catechin Small molecular drug D0V7AA
Cl-5343 Small molecular drug D0VD7H
Coumarin Small molecular drug D03ZMQ
Decane-1,10-diyl Disulfamate Small molecular drug D00YEF
Decyl Sulfamate Small molecular drug D09WSJ
Ellagic Acid Small molecular drug D0A1CM
Ellagic Acid Small molecular drug DB08846
Ethyl 7-methoxy-2-oxo-2h-chromene-3-carboxylate Small molecular drug D07TAJ
Gallicacid Small molecular drug D0Y3TZ
Herniarin Small molecular drug D0U4BB
Hexane-1,6-diamine Small molecular drug D09JPC
N1-(2-aminoethyl)Ethane-1,2-diamine Small molecular drug D09WVV
N1-(Naphthalen-1-yl)Ethane-1,2-diamine Small molecular drug D0X5HL
Octane-1,8-diyl Disulfamate Small molecular drug D0D4OV
Octyl Sulfamate Small molecular drug D05TLB
P-coumaric Acid Small molecular drug D0AU0M
P-toluenesulfonamide Small molecular drug D0ZC3W
Pentane-1,5-diamine Small molecular drug D02QGI
Syringic Acid Small molecular drug D0Q7DJ
4-(2-hydroxy-ethyl)-benzenesulfonamide . D04VLI
4-amino-3-bromo-benzenesulfonamide . D0P6AM
4-amino-3-fluoro-benzenesulfonamide . D04CVC
4-amino-3-iodo-benzenesulfonamide . D01STY
6-hydroxy-benzothiazole-2-sulfonic Acid Amide . D0Q2LL
Patented
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ferulic Acid Small molecular drug D03SLR
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Spermine Small molecular drug D0LD9S

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.