Details of the Target

General Information of Target

Target ID LDTP03204
Target Name DNA repair protein complementing XP-A cells (XPA)
Gene Name XPA
Gene ID 7507
Synonyms
XPAC; DNA repair protein complementing XP-A cells; Xeroderma pigmentosum group A-complementing protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAADGALPEAAALEQPAELPASVRASIERKRQRALMLRQARLAARPYSATAAAATGGMA
NVKAAPKIIDTGGGFILEEEEEEEQKIGKVVHQPGPVMEFDYVICEECGKEFMDSYLMNH
FDLPTCDNCRDADDKHKLITKTEAKQEYLLKDCDLEKREPPLKFIVKKNPHHSQWGDMKL
YLKLQIVKRSLEVWGSQEALEEAKEVRQENREKMKQKKFDKKVKELRRAVRSSVWKRETI
VHQHEYGPEENLEDDMYRKTCTMCGHELTYEKM
Target Type
Literature-reported
Target Bioclass
Other
Family
XPA family
Subcellular location
Nucleus
Function
Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.
TTD ID
T48040
Uniprot ID
P23025
DrugMap ID
TTGT87E
Ensemble ID
ENST00000375128.5
HGNC ID
HGNC:12814
ChEMBL ID
CHEMBL4105801

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C153(3.05)  LDD0168  [1]
DBIA
 Probe Info  		C126(0.99); C129(0.99); C105(1.08); C108(1.08)  LDD0080  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]
NAIA_5
 Probe Info  		N.A.  LDD2224  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C153(3.05)  LDD0168  [1]
 LDCM0022  KB02 HCT 116 C126(0.99); C129(0.99); C105(1.08); C108(1.08)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C126(1.40); C129(1.40); C105(1.51); C108(1.51)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C126(1.91); C129(1.91); C105(1.64); C108(1.64)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-directed RNA polymerases I and III subunit RPAC1 (POLR1C) Archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family O15160
DNA excision repair protein ERCC-1 (ERCC1) ERCC1/RAD10/SWI10 family P07992
Proteasome subunit beta type-1 (PSMB1) Peptidase T1B family P20618
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) Sirtuin family Q96EB6
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
E3 ubiquitin-protein ligase HERC2 (HERC2) . O95714
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 655 (ZNF655) Krueppel C2H2-type zinc-finger protein family Q8N720
AT-rich interactive domain-containing protein 3A (ARID3A) . Q99856
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pre-mRNA-splicing factor SYF1 (XAB2) Crooked-neck family Q9HCS7
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
Nuclear distribution protein nudE-like 1 (NDEL1) NudE family Q9GZM8
Replication protein A 32 kDa subunit (RPA2) Replication factor A protein 2 family P15927
Ski-like protein (SKIL) SKI family P12757
Vacuolar protein sorting-associated protein 26C (VPS26C) VPS26 family O14972
PRKCA-binding protein (PICK1) . Q9NRD5
Syntaphilin (SNPH) . O15079
TBC1 domain family member 7 (TBC1D7) . Q9P0N9

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264