Details of the Target

General Information of Target

Target ID LDTP03117
Target Name Synaptotagmin-1 (SYT1)
Gene Name SYT1
Gene ID 6857
Synonyms
SVP65; SYT; Synaptotagmin-1; Synaptotagmin I; SytI; p65
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVSESHHEALAAPPVTTVATVLPSNATEPASPGEGKEDAFSKLKEKFMNELHKIPLPPWA
LIAIAIVAVLLVLTCCFCICKKCLFKKKNKKKGKEKGGKNAINMKDVKDLGKTMKDQALK
DDDAETGLTDGEEKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDP
YVKVFLLPDKKKKFETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDI
IGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKNL
KKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVV
TVLDYDKIGKNDAIGKVFVGYNSTGAELRHWSDMLANPRRPIAQWHTLQVEEEVDAMLAV
KK
Target Bioclass
Transporter and channel
Family
Synaptotagmin family
Subcellular location
Cytoplasmic vesicle, secretory vesicle membrane
Function
Calcium sensor that participates in triggering neurotransmitter release at the synapse. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes.
Uniprot ID
P21579
Ensemble ID
ENST00000261205.9
HGNC ID
HGNC:11509

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		10.00  LDD0318  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Chondroitin sulfate N-acetylgalactosaminyltransferase 2 (CSGALNACT2) Chondroitin N-acetylgalactosaminyltransferase family Q8N6G5
Cytochrome b5 type B (CYB5B) Cytochrome b5 family O43169
Heme oxygenase 2 (HMOX2) Heme oxygenase family P30519
GTPase IMAP family member 5 (GIMAP5) AIG1/Toc34/Toc159-like paraseptin GTPase family Q96F15
UbiA prenyltransferase domain-containing protein 1 (UBIAD1) UbiA prenyltransferase family Q9Y5Z9
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 (BNIP2) . Q12982
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lens fiber major intrinsic protein (MIP) MIP/aquaporin (TC 1.A.8) family P30301
Transmembrane protein 14C (TMEM14C) TMEM14 family Q9P0S9
Transmembrane protein 60 (TMEM60) . Q9H2L4
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Thyrotropin receptor (TSHR) G-protein coupled receptor 1 family P16473
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Butyrophilin subfamily 2 member A2 (BTN2A2) BTN/MOG family Q8WVV5
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beta-soluble NSF attachment protein (NAPB) SNAP family Q9H115
Zinc finger protein-like 1 (ZFPL1) ZFPL1 family O95159
NF-kappa-B essential modulator (IKBKG) . Q9Y6K9
Transmembrane protein 254 (TMEM254) . Q8TBM7

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580