Details of the Target

General Information of Target

Target ID LDTP03076
Target Name Endothelin-2 (EDN2)
Gene Name EDN2
Gene ID 1907
Synonyms
Endothelin-2; ET-2; Preproendothelin-2; PPET2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVSVPTTWCSVALALLVALHEGKGQAAATLEQPASSSHAQGTHLRLRRCSCSSWLDKECV
YFCHLDIIWVNTPEQTAPYGLGNPPRRRRRSLPRRCQCSSARDPACATFCLRRPWTEAGA
VPSRKSPADVFQTGKTGATTGELLQRLRDISTVKSLFAKRQQEAMREPRSTHSRWRKR
Target Type
Literature-reported
Target Bioclass
Other
Family
Endothelin/sarafotoxin family
Subcellular location
Secreted
Function Endothelins are endothelium-derived vasoconstrictor peptides.
TTD ID
T48358
Uniprot ID
P20800
DrugMap ID
TTMR0OP
Ensemble ID
ENST00000372587.5
HGNC ID
HGNC:3177

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AF-1
 Probe Info  		1.88  LDD0421  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0166  Afatinib A431 1.88  LDD0421  [1]

References

1 Minimalist linkers suitable for irreversible inhibitors in simultaneous proteome profiling, live-cell imaging and drug screening. Chem Commun (Camb). 2019 Jan 15;55(6):834-837. doi: 10.1039/c8cc08685k.