Details of the Target

General Information of Target

Target ID LDTP02967
Target Name Cyclic AMP-dependent transcription factor ATF-1 (ATF1)
Gene Name ATF1
Gene ID 466
Synonyms
Cyclic AMP-dependent transcription factor ATF-1; cAMP-dependent transcription factor ATF-1; Activating transcription factor 1; Protein TREB36
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILAR
RPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQL
ASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQ
IRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKC
LENRVAVLENQNKTLIEELKTLKDLYSNKSV
Target Bioclass
Transcription factor
Family
BZIP family, ATF subfamily
Subcellular location
Nucleus
Function
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.
Uniprot ID
P18846
Ensemble ID
ENST00000262053.8
HGNC ID
HGNC:783
ChEMBL ID
CHEMBL3255

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
FADU SNV: p.H27Y .
HDQP1 SNV: p.R182L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C240(0.95)  LDD1700  [2]
Acrolein
 Probe Info  		N.A.  LDD0221  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]
AOyne
 Probe Info  		15.00  LDD0443  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C230(0.89); C240(0.70)  LDD2117  [2]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C240(0.43)  LDD2132  [2]
 LDCM0107  IAA HeLa N.A.  LDD0221  [3]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C240(0.48)  LDD2121  [2]
 LDCM0109  NEM HeLa N.A.  LDD0223  [3]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C230(1.17)  LDD2090  [2]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C230(0.63)  LDD2092  [2]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C230(1.31)  LDD2094  [2]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C240(0.67)  LDD2096  [2]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C240(0.56)  LDD2098  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C230(0.90)  LDD2099  [2]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C230(1.81); C240(2.02)  LDD2105  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C230(0.73)  LDD2109  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C230(0.84)  LDD2111  [2]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C230(0.92)  LDD2118  [2]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C230(0.47); C240(0.47)  LDD2122  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C230(0.53); C240(1.10)  LDD2123  [2]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C230(0.96)  LDD2124  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C230(0.68)  LDD2125  [2]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C240(0.55)  LDD2126  [2]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C240(0.94)  LDD2128  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C230(0.64)  LDD2129  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C230(0.74); C240(1.03)  LDD2135  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C230(0.98)  LDD2136  [2]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C240(0.95)  LDD1700  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C230(0.63)  LDD2140  [2]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C230(1.03); C240(0.77)  LDD2143  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C230(2.43); C240(1.91)  LDD2144  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C230(0.77)  LDD2146  [2]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C240(0.35)  LDD2150  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 1 (CREB1) BZIP family P16220
Cyclic AMP-dependent transcription factor ATF-1 (ATF1) BZIP family P18846
Transcription factor Jun (JUN) BZIP family P05412
Nuclear factor interleukin-3-regulated protein (NFIL3) BZIP family Q16649
Estrogen receptor (ESR1) Nuclear hormone receptor family P03372
Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) . O95644

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pseudoephedrine Small molecular drug DB00852

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.