Details of the Target

General Information of Target

Target ID LDTP02904
Target Name Creatine kinase S-type, mitochondrial (CKMT2)
Gene Name CKMT2
Gene ID 1160
Synonyms
Creatine kinase S-type, mitochondrial; EC 2.7.3.2; Basic-type mitochondrial creatine kinase; Mib-CK; Sarcomeric mitochondrial creatine kinase; S-MtCK
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASIFSKLLTGRNASLLFATMGTSVLTTGYLLNRQKVCAEVREQPRLFPPSADYPDLRKH
NNCMAECLTPAIYAKLRNKVTPNGYTLDQCIQTGVDNPGHPFIKTVGMVAGDEESYEVFA
DLFDPVIKLRHNGYDPRVMKHTTDLDASKITQGQFDEHYVLSSRVRTGRSIRGLSLPPAC
TRAERREVENVAITALEGLKGDLAGRYYKLSEMTEQDQQRLIDDHFLFDKPVSPLLTCAG
MARDWPDARGIWHNYDKTFLIWINEEDHTRVISMEKGGNMKRVFERFCRGLKEVERLIQE
RGWEFMWNERLGYILTCPSNLGTGLRAGVHVRIPKLSKDPRFSKILENLRLQKRGTGGVD
TAAVADVYDISNIDRIGRSEVELVQIVIDGVNYLVDCEKKLERGQDIKVPPPLPQFGKK
Target Bioclass
Enzyme
Family
ATP:guanido phosphotransferase family
Subcellular location
Mitochondrion inner membrane
Function
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
Uniprot ID
P17540
Ensemble ID
ENST00000254035.9
HGNC ID
HGNC:1996

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C210(1.32)  LDD3310  [1]
AHL-Pu-1
 Probe Info  		C317(3.33)  LDD0169  [2]
IA-alkyne
 Probe Info  		C317(0.65)  LDD2206  [3]
ENE
 Probe Info  		N.A.  LDD0006  [4]
IPM
 Probe Info  		N.A.  LDD0005  [4]
VSF
 Probe Info  		C317(0.00); C38(0.00)  LDD0007  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C317(3.33)  LDD0169  [2]
 LDCM0022  KB02 22RV1 C210(0.61)  LDD2243  [1]
 LDCM0023  KB03 22RV1 C210(0.63)  LDD2660  [1]
 LDCM0024  KB05 COLO792 C210(1.32)  LDD3310  [1]
 LDCM0627  NUDT7-COV-1 HEK-293T C317(0.65)  LDD2206  [3]
 LDCM0628  OTUB2-COV-1 HEK-293T C317(0.69)  LDD2207  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Prolyl 4-hydroxylase subunit alpha-3 (P4HA3) P4HA family Q7Z4N8
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centrin-3 (CETN3) Centrin family O15182
Kelch-like protein 42 (KLHL42) . Q9P2K6

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Acyclovir Small molecular drug DB00787
Creatine Small molecular drug DB00148
Tenofovir Disoproxil Small molecular drug DB00300
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Phosphocreatine . DB13191

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764