Details of the Target
General Information of Target
| Target ID | LDTP02811 | |||||
|---|---|---|---|---|---|---|
| Target Name | Transcription factor 4 (TCF4) | |||||
| Gene Name | TCF4 | |||||
| Gene ID | 6925 | |||||
| Synonyms |
BHLHB19; ITF2; SEF2; Transcription factor 4; TCF-4; Class B basic helix-loop-helix protein 19; bHLHb19; Immunoglobulin transcription factor 2; ITF-2; SL3-3 enhancer factor 2; SEF-2 |
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| 3D Structure | ||||||
| Sequence |
MHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWG
NGGHPSPSRNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQSKTERGSYSSYGRESNLQG CHQQSLLGGDMDMGNPGTLSPTKPGSQYYQYSSNNPRRRPLHSSAMEVQTKKVRKVPPGL PSSVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAG MLGNSSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPA NGTDSIMANRGSGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTA VWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRNHAVGPSTAMPGGHGDMHG IIGPSHNGAMGGLGSGYGTGLLSANRHSLMVGTHREDGVALRGSHSLLPNQVPVPQLPVQ SATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKLDDDKKD IKSITSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKP QTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSSEPPPLSLAGPHPGMGDA SNHMGQM |
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| Target Bioclass |
Transcription factor
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| Subcellular location |
Nucleus
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| Function |
Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription. Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
IA-alkyne Probe Info |
 |
C296(1.12) | LDD2183 | [1] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0625 | F8 | Ramos | C296(1.70) | LDD2187 | [1] |
| LDCM0572 | Fragment10 | Ramos | C296(2.28) | LDD2189 | [1] |
| LDCM0573 | Fragment11 | Ramos | C296(5.32) | LDD2190 | [1] |
| LDCM0574 | Fragment12 | Ramos | C296(1.06) | LDD2191 | [1] |
| LDCM0575 | Fragment13 | Ramos | C296(0.77) | LDD2192 | [1] |
| LDCM0576 | Fragment14 | Ramos | C296(0.59) | LDD2193 | [1] |
| LDCM0579 | Fragment20 | Ramos | C296(0.87) | LDD2194 | [1] |
| LDCM0580 | Fragment21 | Ramos | C296(0.67) | LDD2195 | [1] |
| LDCM0582 | Fragment23 | Ramos | C296(1.08) | LDD2196 | [1] |
| LDCM0578 | Fragment27 | Ramos | C296(1.13) | LDD2197 | [1] |
| LDCM0586 | Fragment28 | Ramos | C296(0.63) | LDD2198 | [1] |
| LDCM0588 | Fragment30 | Ramos | C296(2.23) | LDD2199 | [1] |
| LDCM0589 | Fragment31 | Ramos | C296(0.72) | LDD2200 | [1] |
| LDCM0590 | Fragment32 | Ramos | C296(1.34) | LDD2201 | [1] |
| LDCM0468 | Fragment33 | Ramos | C296(1.57) | LDD2202 | [1] |
| LDCM0596 | Fragment38 | Ramos | C296(0.74) | LDD2203 | [1] |
| LDCM0566 | Fragment4 | Ramos | C296(0.83) | LDD2184 | [1] |
| LDCM0610 | Fragment52 | Ramos | C296(1.27) | LDD2204 | [1] |
| LDCM0571 | Fragment9 | Ramos | C296(1.36) | LDD2188 | [1] |
| LDCM0023 | KB03 | Ramos | C296(1.12) | LDD2183 | [1] |