Details of the Target

General Information of Target

Target ID LDTP02731
Target Name Neutrophil cytosol factor 1 (NCF1)
Gene Name NCF1
Gene ID 653361
Synonyms
NOXO2; SH3PXD1A; Neutrophil cytosol factor 1; NCF-1; 47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; NCF-47K; Neutrophil NADPH oxidase factor 1; Nox organizer 2; Nox-organizing protein 2; SH3 and PX domain-containing protein 1A; p47-phox
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGDTFIRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPI
EAGAINPENRIIPHLPAPKWFDGQRAAENRQGTLTEYCSTLMSLPTKISRCPHLLDFFKV
RPDDLKLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALSTG
DVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKAYTAV
EGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPP
RRSSIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQRRRQARPGPQSPGSPLEEERQTQRSK
PQPAVPPRPSADLILNRCSESTKRKLASAV
Target Type
Literature-reported
Target Bioclass
Other
Subcellular location
Cytoplasm, cytosol
Function NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
TTD ID
T47492
Uniprot ID
P14598
DrugMap ID
TTZ4JC3
Ensemble ID
ENST00000289473.11
HGNC ID
HGNC:7660
ChEMBL ID
CHEMBL1613743

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C378(2.30); C111(0.92)  LDD2182  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C378(0.73); C111(1.25)  LDD2187  [1]
 LDCM0572  Fragment10 Ramos C378(2.39); C111(0.86)  LDD2189  [1]
 LDCM0573  Fragment11 Ramos C378(0.31); C111(0.42)  LDD2190  [1]
 LDCM0574  Fragment12 Ramos C378(0.98); C111(1.16)  LDD2191  [1]
 LDCM0575  Fragment13 Ramos C378(0.67); C111(1.75)  LDD2192  [1]
 LDCM0576  Fragment14 Ramos C378(0.43); C111(0.96)  LDD2193  [1]
 LDCM0579  Fragment20 Ramos C378(0.69); C111(1.01)  LDD2194  [1]
 LDCM0580  Fragment21 Ramos C378(0.57); C111(1.03)  LDD2195  [1]
 LDCM0582  Fragment23 Ramos C378(1.15); C111(0.46)  LDD2196  [1]
 LDCM0578  Fragment27 Ramos C378(0.63); C111(1.46)  LDD2197  [1]
 LDCM0586  Fragment28 Ramos C378(0.68); C111(2.12)  LDD2198  [1]
 LDCM0588  Fragment30 Ramos C378(0.92); C111(1.25)  LDD2199  [1]
 LDCM0589  Fragment31 Ramos C378(0.51); C111(1.23)  LDD2200  [1]
 LDCM0590  Fragment32 Ramos C378(1.88); C111(0.90)  LDD2201  [1]
 LDCM0468  Fragment33 Ramos C378(1.02); C111(1.41)  LDD2202  [1]
 LDCM0596  Fragment38 Ramos C378(0.56); C111(3.05)  LDD2203  [1]
 LDCM0566  Fragment4 Ramos C378(0.73); C111(0.87)  LDD2184  [1]
 LDCM0610  Fragment52 Ramos C378(0.68); C111(3.12)  LDD2204  [1]
 LDCM0614  Fragment56 Ramos C378(0.91); C111(1.15)  LDD2205  [1]
 LDCM0569  Fragment7 Ramos C378(0.77); C111(0.82)  LDD2186  [1]
 LDCM0571  Fragment9 Ramos C378(1.23); C111(0.87)  LDD2188  [1]
 LDCM0022  KB02 Ramos C378(2.30); C111(0.92)  LDD2182  [1]
 LDCM0023  KB03 Ramos C378(0.59); C111(0.82)  LDD2183  [1]
 LDCM0024  KB05 Ramos C378(0.88); C111(0.65)  LDD2185  [1]

References

1 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578