Details of the Target

General Information of Target

Target ID LDTP02687
Target Name Bone marrow proteoglycan (PRG2)
Gene Name PRG2
Gene ID 5553
Synonyms
MBP; Bone marrow proteoglycan; BMPG; Proteoglycan 2) [Cleaved into: Eosinophil granule major basic protein; EMBP; MBP; Pregnancy-associated major basic protein)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKLPLLLALLFGAVSALHLRSETSTFETPLGAKTLPEDEETPEQEMEETPCRELEEEEEW
GSGSEDASKKDGAVESISVPDMVDKNLTCPEEEDTVKVVGIPGCQTCRYLLVRSLQTFSQ
AWFTCRRCYRGNLVSIHNFNINYRIQCSVSALNQGQVWIGGRITGSGRCRRFQWVDGSRW
NFAYWAAHQPWSRGGHCVALCTRGGHWRRAHCLRRLPFICSY
Target Bioclass
Other
Subcellular location
Secreted; Cytoplasmic vesicle, secretory vesicle
Function
Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.
Uniprot ID
P13727
Ensemble ID
ENST00000311862.10
HGNC ID
HGNC:9362

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 SNV: p.R170K .
JHH7 Substitution: p.E45M .
LOXIMVI SNV: p.G72R .
NCIH1666 SNV: p.I136N .
OVK18 SNV: p.A210V .
RL SNV: p.F172V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C147(2.55); C220(1.94); C125(3.18)  LDD3333  [1]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 EoL-1 C147(1.47)  LDD2324  [1]
 LDCM0023  KB03 EoL-1 C147(1.83)  LDD2741  [1]
 LDCM0024  KB05 MOLM-13 C147(2.55); C220(1.94); C125(3.18)  LDD3333  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pappalysin-1 (PAPPA) Peptidase M43B family Q13219

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Sargramostim BiotechDrug DB00020
Chymopapain . DB06752

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.