Details of the Target

General Information of Target

Target ID LDTP02673
Target Name Metallothionein-1G (MT1G)
Gene Name MT1G
Gene ID 4495
Synonyms
MT1K; MT1M; Metallothionein-1G; MT-1G; Metallothionein-1K; MT-1K; Metallothionein-IG; MT-IG
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDPNCSCAAAGVSCTCASSCKCKECKCTSCKKSCCSCCPVGCAKCAQGCICKGASEKCSC
CA
Target Bioclass
Other
Family
Metallothionein superfamily, Type 1 family
Function Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Uniprot ID
P13640
Ensemble ID
ENST00000379811.4
HGNC ID
HGNC:7399

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C45(1.45); C49(1.45); C37(1.51); C42(1.51)  LDD0080  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0369  CL100 HEK-293T C45(0.77); C49(0.77); C51(0.77)  LDD1573  [2]
 LDCM0373  CL104 HEK-293T C45(0.82); C49(0.82); C51(0.82)  LDD1577  [2]
 LDCM0377  CL108 HEK-293T C45(1.05); C49(1.05); C51(1.05)  LDD1581  [2]
 LDCM0382  CL112 HEK-293T C45(1.02); C49(1.02); C51(1.02)  LDD1586  [2]
 LDCM0386  CL116 HEK-293T C45(1.08); C49(1.08); C51(1.08)  LDD1590  [2]
 LDCM0391  CL120 HEK-293T C45(0.93); C49(0.93); C51(0.93)  LDD1595  [2]
 LDCM0395  CL124 HEK-293T C45(0.96); C49(0.96); C51(0.96)  LDD1599  [2]
 LDCM0399  CL128 HEK-293T C45(0.71); C49(0.71); C51(0.71)  LDD1603  [2]
 LDCM0403  CL16 HEK-293T C45(1.25); C49(1.25); C51(1.25)  LDD1607  [2]
 LDCM0416  CL28 HEK-293T C45(1.20); C49(1.20); C51(1.20)  LDD1620  [2]
 LDCM0429  CL4 HEK-293T C45(1.21); C49(1.21); C51(1.21)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C45(1.07); C49(1.07); C51(1.07)  LDD1634  [2]
 LDCM0443  CL52 HEK-293T C45(1.00); C49(1.00); C51(1.00)  LDD1646  [2]
 LDCM0456  CL64 HEK-293T C45(1.20); C49(1.20); C51(1.20)  LDD1659  [2]
 LDCM0469  CL76 HEK-293T C45(0.74); C49(0.74); C51(0.74)  LDD1672  [2]
 LDCM0482  CL88 HEK-293T C45(0.86); C49(0.86); C51(0.86)  LDD1685  [2]
 LDCM0022  KB02 HCT 116 C45(1.45); C49(1.45); C37(1.51); C42(1.51)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C45(1.93); C49(1.93); C37(1.16); C42(1.16)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C45(1.52); C49(1.52); C37(1.25); C42(1.25)  LDD0082  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402