Details of the Target

General Information of Target

Target ID LDTP02657
Target Name Bone morphogenetic protein 1 (BMP1)
Gene Name BMP1
Gene ID 649
Synonyms
PCOLC; Bone morphogenetic protein 1; BMP-1; EC 3.4.24.19; Mammalian tolloid protein; mTld; Procollagen C-proteinase; PCP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPGVARLPLLLGLLLLPRPGRPLDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE
EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRR
AATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY
RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN
IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG
QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI
ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS
NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF
EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF
AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNG
SITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSK
LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVN
TFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISST
PGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLR
FYSDNSVQRKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGY
GVELVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHS
DDTITKKGFHLRYTSTKFQDTLHSRK
Target Type
Literature-reported
Target Bioclass
Enzyme
Subcellular location
Secreted; Golgi apparatus, trans-Golgi network
Function
Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins. Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair. Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross-links in collagen and elastic fibers. Additional substrates include matricellular thrombospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation.; [Isoform BMP1-3]: Plays an important role in bone repair by acting as a coactivator of BMP7.
TTD ID
T53350
Uniprot ID
P13497
DrugMap ID
TT0L58T
Ensemble ID
ENST00000306349.13
HGNC ID
HGNC:1067
ChEMBL ID
CHEMBL3898

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA Deletion: p.N614TfsTer138 .
CHL1 SNV: p.G823E .
JURKAT SNV: p.Q716Ter .
KYSE510 SNV: p.D961N .
MEWO SNV: p.G713A .
MFE319 SNV: p.A273T .
NB4 SNV: p.Q242H .
SW948 SNV: p.S835C .
TGBC1TKB SNV: p.D803G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C617(0.91)  LDD0078  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0237  AC12 HEK-293T C551(1.17)  LDD1510  [2]
 LDCM0280  AC20 HEK-293T C551(0.97)  LDD1519  [2]
 LDCM0288  AC28 HEK-293T C551(1.09)  LDD1527  [2]
 LDCM0297  AC36 HEK-293T C551(1.24)  LDD1536  [2]
 LDCM0301  AC4 HEK-293T C551(1.08)  LDD1540  [2]
 LDCM0306  AC44 HEK-293T C551(1.14)  LDD1545  [2]
 LDCM0315  AC52 HEK-293T C551(1.03)  LDD1554  [2]
 LDCM0324  AC60 HEK-293T C551(1.05)  LDD1563  [2]
 LDCM0020  ARS-1620 HCC44 C617(0.91)  LDD0078  [1]
 LDCM0408  CL20 HEK-293T C551(1.09)  LDD1612  [2]
 LDCM0421  CL32 HEK-293T C551(1.04)  LDD1625  [2]
 LDCM0434  CL44 HEK-293T C551(0.97)  LDD1638  [2]
 LDCM0447  CL56 HEK-293T C551(1.22)  LDD1650  [2]
 LDCM0460  CL68 HEK-293T C551(1.00)  LDD1663  [2]
 LDCM0473  CL8 HEK-293T C551(1.16)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C551(0.98)  LDD1677  [2]
 LDCM0487  CL92 HEK-293T C551(1.13)  LDD1690  [2]
 LDCM0022  KB02 A101D C551(2.62)  LDD2250  [3]
 LDCM0023  KB03 A101D C551(2.52)  LDD2667  [3]
 LDCM0024  KB05 COLO792 C551(1.48)  LDD3310  [3]
 LDCM0021  THZ1 HCT 116 C617(0.94)  LDD2173  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bone morphogenetic protein 1 (BMP1) . P13497
Procollagen C-endopeptidase enhancer 1 (PCOLCE) . Q15113
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Chordin (CHRD) Chordin family Q9H2X0
Collagen alpha-1(V) chain (COL5A1) Fibrillar collagen family P20908
Decorin (DCN) Small leucine-rich proteoglycan (SLRP) family P07585
Growth/differentiation factor 8 (MSTN) TGF-beta family O14793

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid11934595c2 Small molecular drug D02DQT
Uk-383367 Small molecular drug D0P2TS

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840