Details of the Target

General Information of Target

Target ID LDTP02591
Target Name B-lymphocyte antigen CD20 (MS4A1)
Gene Name MS4A1
Gene ID 931
Synonyms
CD20; B-lymphocyte antigen CD20; B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; CD antigen CD20
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTTPRNSVNGTFPAEPMKGPIAMQSGPKPLFRRMSSLVGPTQSFFMRESKTLGAVQIMNG
LFHIALGGLLMIPAGIYAPICVTVWYPLWGGIMYIISGSLLAATEKNSRKCLVKGKMIMN
SLSLFAAISGMILSIMDILNIKISHFLKMESLNFIRAHTPYINIYNCEPANPSEKNSPST
QYCYSIQSLFLGILSVMLIFAFFQELVIAGIVENEWKRTCSRPKSNIVLLSAEEKKEQTI
EIKEEVVGLTETSSQPKNEEDIEIIPIQEEEEEETETNFPEPPQDQESSPIENDSSP
Target Type
Successful
Target Bioclass
Transporter and channel
Family
MS4A family
Subcellular location
Cell membrane
Function
B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR.
TTD ID
T73215
Uniprot ID
P11836
DrugMap ID
TTUE541
Ensemble ID
ENST00000345732.9
HGNC ID
HGNC:7315
ChEMBL ID
CHEMBL2058

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL120 SNV: p.R47W .
COLO320 SNV: p.E263D .
HT3 SNV: p.Q24E .
MEWO SNV: p.E168K .
SW1271 SNV: p.P160T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C167(1.43)  LDD2355  [1]
IA-alkyne
 Probe Info  		C167(2.32); C220(1.86)  LDD2182  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C167(1.47); C220(1.92)  LDD2187  [2]
 LDCM0572  Fragment10 Ramos C167(2.13); C220(1.99)  LDD2189  [2]
 LDCM0573  Fragment11 Ramos C167(0.34); C220(9.80)  LDD2190  [2]
 LDCM0574  Fragment12 Ramos C167(3.15)  LDD2191  [2]
 LDCM0575  Fragment13 Ramos C167(1.12); C220(0.62)  LDD2192  [2]
 LDCM0576  Fragment14 Ramos C167(2.53); C220(1.78)  LDD2193  [2]
 LDCM0579  Fragment20 Ramos C167(3.40)  LDD2194  [2]
 LDCM0580  Fragment21 Ramos C167(0.91); C220(0.55)  LDD2195  [2]
 LDCM0582  Fragment23 Ramos C167(0.94); C220(4.48)  LDD2196  [2]
 LDCM0578  Fragment27 Ramos C167(0.94)  LDD2197  [2]
 LDCM0586  Fragment28 Ramos C167(0.66); C220(0.70)  LDD2198  [2]
 LDCM0588  Fragment30 Ramos C167(1.52); C220(0.73)  LDD2199  [2]
 LDCM0589  Fragment31 Ramos C167(0.81); C220(1.66)  LDD2200  [2]
 LDCM0590  Fragment32 Ramos C167(2.08)  LDD2201  [2]
 LDCM0468  Fragment33 Ramos C167(1.23); C220(1.64)  LDD2202  [2]
 LDCM0596  Fragment38 Ramos C167(1.23)  LDD2203  [2]
 LDCM0566  Fragment4 Ramos C167(1.94); C220(1.24)  LDD2184  [2]
 LDCM0610  Fragment52 Ramos C167(2.04)  LDD2204  [2]
 LDCM0614  Fragment56 Ramos C167(1.42); C220(0.70)  LDD2205  [2]
 LDCM0569  Fragment7 Ramos C167(2.15); C220(1.70)  LDD2186  [2]
 LDCM0571  Fragment9 Ramos C167(3.88); C220(1.12)  LDD2188  [2]
 LDCM0022  KB02 Ramos C167(2.32); C220(1.86)  LDD2182  [2]
 LDCM0023  KB03 Ramos C167(2.34)  LDD2183  [2]
 LDCM0024  KB05 Ramos C167(2.90)  LDD2185  [2]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578