Details of the Target

General Information of Target

Target ID LDTP02536
Target Name Leukocyte antigen CD37 (CD37)
Gene Name CD37
Gene ID 951
Synonyms
TSPAN26; Leukocyte antigen CD37; Tetraspanin-26; Tspan-26; CD antigen CD37
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSAQESCLSLIKYFLFVFNLFFFVLGSLIFCFGIWILIDKTSFVSFVGLAFVPLQIWSKV
LAISGIFTMGIALLGCVGALKELRCLLGLYFGMLLLLFATQITLGILISTQRAQLERSLR
DVVEKTIQKYGTNPEETAAEESWDYVQFQLRCCGWHYPQDWFQVLILRGNGSEAHRVPCS
CYNLSATNDSTILDKVILPQLSRLGHLARSRHSADICAVPAESHIYREGCAQGLQKWLHN
NLISIVGICLGVGLLELGFMTLSIFLCRNLDHVYNRLARYR
Target Type
Clinical trial
Target Bioclass
Other
Family
Tetraspanin (TM4SF) family
Subcellular location
Membrane
TTD ID
T97111
Uniprot ID
P11049
DrugMap ID
TTFCW29
Ensemble ID
ENST00000323906.9
HGNC ID
HGNC:1666
ChEMBL ID
CHEMBL3712880

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
Ishikawa (Heraklio) 02 ER SNV: p.P53H .
P31FUJ SNV: p.R84C .
REH SNV: p.A72T .
RL952 SNV: p.G26S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C217(1.53)  LDD3372  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0166  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C230(1.20); C217(4.34)  LDD2187  [3]
 LDCM0573  Fragment11 Ramos C230(0.62)  LDD2190  [3]
 LDCM0575  Fragment13 Ramos C230(1.29); C217(0.74)  LDD2192  [3]
 LDCM0576  Fragment14 Ramos C217(1.22)  LDD2193  [3]
 LDCM0580  Fragment21 Ramos C230(1.46); C217(0.50)  LDD2195  [3]
 LDCM0582  Fragment23 Ramos C230(0.88)  LDD2196  [3]
 LDCM0578  Fragment27 Ramos C230(1.15)  LDD2197  [3]
 LDCM0586  Fragment28 Ramos C230(1.09); C217(0.74)  LDD2198  [3]
 LDCM0588  Fragment30 Ramos C230(1.91); C217(1.33)  LDD2199  [3]
 LDCM0589  Fragment31 Ramos C230(1.48); C217(1.39)  LDD2200  [3]
 LDCM0468  Fragment33 Ramos C230(3.34); C217(1.03)  LDD2202  [3]
 LDCM0596  Fragment38 Ramos C230(3.00); C217(4.24)  LDD2203  [3]
 LDCM0566  Fragment4 Ramos C217(1.90)  LDD2184  [3]
 LDCM0610  Fragment52 Ramos C230(2.44)  LDD2204  [3]
 LDCM0614  Fragment56 Ramos C230(1.86); C217(1.07)  LDD2205  [3]
 LDCM0569  Fragment7 Ramos C230(3.12); C217(1.03)  LDD2186  [3]
 LDCM0022  KB02 Ramos C217(1.94)  LDD2182  [3]
 LDCM0023  KB03 Ramos C217(1.30)  LDD2183  [3]
 LDCM0024  KB05 OCI-Ly3 C217(1.53)  LDD3372  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tyrosine-protein kinase Lyn (LYN) Tyr protein kinase family P07948
Tyrosine-protein kinase SYK (SYK) Tyr protein kinase family P43405
Tyrosine-protein phosphatase non-receptor type 6 (PTPN6) Protein-tyrosine phosphatase family P29350
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gap junction beta-1 protein (GJB1) Connexin family P08034
LHFPL tetraspan subfamily member 5 protein (LHFPL5) LHFP family Q8TAF8
Leukocyte surface antigen CD53 (CD53) Tetraspanin (TM4SF) family P19397
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leucine-rich repeat-containing protein 3B (LRRC3B) LRRC3 family Q96PB8
Epithelial membrane protein 1 (EMP1) PMP-22/EMP/MP20 family P54849

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 6 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bi-836826 Antibody D09WKM
Gen3009 Antibody D1W2DS
Imgn529 Antibody D0C0LO
Naratuximab Emtansine Antibody D2R0UM
Otlertuzumab . D08JGB
Tru-016 . D0T7QC
Preclinical
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
212pb-labelled Acd37 Radiopharmaceutical therapy DI9ZQ6

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578