Details of the Target

General Information of Target

Target ID LDTP02472
Target Name Calcitonin gene-related peptide 2 (CALCB)
Gene Name CALCB
Gene ID 797
Synonyms
CALC2; Calcitonin gene-related peptide 2; Beta-type CGRP; Beta-CGRP; Calcitonin gene-related peptide II; CGRP-II
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGFRKFSPFLALSILVLYQAGSLQAAPFRSALESSPDPATLSKEDARLLLAALVQDYVQM
KASELKQEQETQGSSSAAQKRACNTATCVTHRLAGLLSRSGGMVKSNFVPTNVGSKAFGR
RRRDLQA
Target Type
Literature-reported
Target Bioclass
Other
Family
Calcitonin family
Subcellular location
Secreted
Function
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.
TTD ID
T09067
Uniprot ID
P10092
DrugMap ID
TTUZ9GV
Ensemble ID
ENST00000324229.11
HGNC ID
HGNC:1438
ChEMBL ID
CHEMBL3713541

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C83(2.12); C88(2.12)  LDD0080  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C88(1.48)  LDD1509  [2]
 LDCM0237  AC12 HEK-293T C88(1.19)  LDD1510  [2]
 LDCM0278  AC19 HEK-293T C88(1.51)  LDD1517  [2]
 LDCM0280  AC20 HEK-293T C88(1.06)  LDD1519  [2]
 LDCM0287  AC27 HEK-293T C88(1.06)  LDD1526  [2]
 LDCM0288  AC28 HEK-293T C88(1.14)  LDD1527  [2]
 LDCM0290  AC3 HEK-293T C88(1.15)  LDD1529  [2]
 LDCM0296  AC35 HEK-293T C88(1.27)  LDD1535  [2]
 LDCM0297  AC36 HEK-293T C88(1.26)  LDD1536  [2]
 LDCM0301  AC4 HEK-293T C88(1.12)  LDD1540  [2]
 LDCM0305  AC43 HEK-293T C88(1.46)  LDD1544  [2]
 LDCM0306  AC44 HEK-293T C88(1.29)  LDD1545  [2]
 LDCM0314  AC51 HEK-293T C88(1.50)  LDD1553  [2]
 LDCM0315  AC52 HEK-293T C88(1.09)  LDD1554  [2]
 LDCM0322  AC59 HEK-293T C88(1.27)  LDD1561  [2]
 LDCM0324  AC60 HEK-293T C88(1.23)  LDD1563  [2]
 LDCM0406  CL19 HEK-293T C88(1.30)  LDD1610  [2]
 LDCM0408  CL20 HEK-293T C88(1.03)  LDD1612  [2]
 LDCM0420  CL31 HEK-293T C88(1.21)  LDD1624  [2]
 LDCM0421  CL32 HEK-293T C88(1.05)  LDD1625  [2]
 LDCM0433  CL43 HEK-293T C88(1.18)  LDD1637  [2]
 LDCM0434  CL44 HEK-293T C88(1.02)  LDD1638  [2]
 LDCM0446  CL55 HEK-293T C88(1.34)  LDD1649  [2]
 LDCM0447  CL56 HEK-293T C88(1.27)  LDD1650  [2]
 LDCM0459  CL67 HEK-293T C88(1.34)  LDD1662  [2]
 LDCM0460  CL68 HEK-293T C88(1.12)  LDD1663  [2]
 LDCM0462  CL7 HEK-293T C88(1.16)  LDD1665  [2]
 LDCM0472  CL79 HEK-293T C88(1.21)  LDD1675  [2]
 LDCM0473  CL8 HEK-293T C88(1.14)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C88(1.05)  LDD1677  [2]
 LDCM0486  CL91 HEK-293T C88(1.40)  LDD1689  [2]
 LDCM0487  CL92 HEK-293T C88(1.27)  LDD1690  [2]
 LDCM0022  KB02 HCT 116 C83(2.12); C88(2.12)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C83(2.17); C88(2.17)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C83(2.30); C88(2.30)  LDD0082  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402