Details of the Target
General Information of Target
| Target ID | LDTP02442 | |||||
|---|---|---|---|---|---|---|
| Target Name | Calmodulin-2 (CALM2) | |||||
| Gene Name | CALM2 | |||||
| Gene ID | 801 | |||||
| Synonyms |
CAM2; CAMB; Calmodulin-2 |
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| 3D Structure | ||||||
| Sequence |
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE EVDEMIREADIDGDGQVNYEEFVQMMTAK |
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| Target Bioclass |
Other
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| Family |
Calmodulin family
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| Subcellular location |
Cytoplasm, cytoskeleton, spindle
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| Function |
Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Mediates calcium-dependent inactivation of CACNA1C. Positively regulates calcium-activated potassium channel activity of KCNN2.; (Microbial infection) Required for C.violaceum CopC and S.flexneri OspC3 arginine ADP-riboxanase activity.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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AZ-9 Probe Info |
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N.A. | LDD0395 | [1] | |
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Acrolein Probe Info |
 |
H108(0.00); K116(0.00) | LDD0217 | [2] | |
Competitor(s) Related to This Target
The Interaction Atlas With This Target
References