Details of the Target

General Information of Target

Target ID LDTP02327
Target Name POU domain, class 2, transcription factor 2 (POU2F2)
Gene Name POU2F2
Gene ID 5452
Synonyms
OCT2; OTF2; POU domain, class 2, transcription factor 2; Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2; Octamer-binding protein 2; Oct-2; Octamer-binding transcription factor 2; OTF-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVHSSMGAPEIRMSKPLEAEKQGLDSPSEHTDTERNGPDTNHQNPQNKTSPFSVSPTGPS
TKIKAEDPSGDSAPAAPLPPQPAQPHLPQAQLMLTGSQLAGDIQQLLQLQQLVLVPGHHL
QPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQPRAGLPTQAVTRPTLPDPHLS
HPQPPKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTT
ISRFEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLPGRRRKK
RTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRINPCSA
APMLPSPGKPASYSPHMVTPQGGAGTLPLSQASSSLSTTVTTLSSAVGTLHPSRTAGGGG
GGGGAAPPLNSIPSVTPPPPATTNSTNPSPQGSHSAIGLSGLNPSTGPGLWWNPAPYQP
Target Bioclass
Transcription factor
Family
POU transcription factor family, Class-2 subfamily
Subcellular location
Cytoplasm
Function
Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates IL6 expression in B cells with POU2AF1. Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR.; [Isoform 5]: Activates the U2 small nuclear RNA (snRNA) promoter.
Uniprot ID
P09086
Ensemble ID
ENST00000389341.9
HGNC ID
HGNC:9213
ChEMBL ID
CHEMBL3509582

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C187(1.27)  LDD2182  [1]
IPM
 Probe Info  		C346(1.21)  LDD1701  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C358(0.97)  LDD1702  [2]
 LDCM0625  F8 Ramos C187(1.05)  LDD2187  [1]
 LDCM0572  Fragment10 Ramos C187(1.46)  LDD2189  [1]
 LDCM0573  Fragment11 Ramos C187(2.05)  LDD2190  [1]
 LDCM0574  Fragment12 Ramos C187(1.34)  LDD2191  [1]
 LDCM0575  Fragment13 Ramos C187(1.24)  LDD2192  [1]
 LDCM0576  Fragment14 Ramos C187(1.27)  LDD2193  [1]
 LDCM0579  Fragment20 Ramos C187(1.29)  LDD2194  [1]
 LDCM0580  Fragment21 Ramos C187(1.03)  LDD2195  [1]
 LDCM0582  Fragment23 Ramos C187(1.95)  LDD2196  [1]
 LDCM0578  Fragment27 Ramos C187(0.98)  LDD2197  [1]
 LDCM0586  Fragment28 Ramos C187(0.98)  LDD2198  [1]
 LDCM0588  Fragment30 Ramos C187(1.05)  LDD2199  [1]
 LDCM0589  Fragment31 Ramos C187(1.07)  LDD2200  [1]
 LDCM0590  Fragment32 Ramos C187(1.47)  LDD2201  [1]
 LDCM0468  Fragment33 Ramos C187(1.25)  LDD2202  [1]
 LDCM0596  Fragment38 Ramos C187(1.02)  LDD2203  [1]
 LDCM0566  Fragment4 Ramos C187(0.85)  LDD2184  [1]
 LDCM0610  Fragment52 Ramos C187(1.03)  LDD2204  [1]
 LDCM0614  Fragment56 Ramos C187(0.97)  LDD2205  [1]
 LDCM0569  Fragment7 Ramos C187(1.13)  LDD2186  [1]
 LDCM0571  Fragment9 Ramos C187(1.04)  LDD2188  [1]
 LDCM0022  KB02 Ramos C187(1.27)  LDD2182  [1]
 LDCM0023  KB03 MDA-MB-231 C346(1.21)  LDD1701  [2]
 LDCM0024  KB05 Ramos C187(1.77)  LDD2185  [1]

References

1 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761