Details of the Target

General Information of Target

Target ID LDTP02284
Target Name Receptor-type tyrosine-protein phosphatase C (PTPRC)
Gene Name PTPRC
Gene ID 5788
Synonyms
CD45; Receptor-type tyrosine-protein phosphatase C; EC 3.1.3.48; Leukocyte common antigen; L-CA; T200; CD antigen CD45
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPA
STFERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQTPSA
GTDTQTFSGSAANAKLNPTPGSNAISDVPGERSTASTFPTDPVSPLTTTLSLAHHSSAAL
PARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYL
YNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVP
PGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLE
PEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFH
NFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTT
KSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFR
VKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYK
IYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSI
PRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPR
KYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVV
VKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNA
FSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEA
QYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQ
HIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINA
SFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGK
QTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISM
IQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQV
VKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDAN
CVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Protein-tyrosine phosphatase family, Receptor class 1/6 subfamily
Subcellular location
Cell membrane
Function
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity.; (Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation.
TTD ID
T43115
Uniprot ID
P08575
DrugMap ID
TTUS45N
Ensemble ID
ENST00000348564.11
HGNC ID
HGNC:9666
ChEMBL ID
CHEMBL3243

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C367(36.74)  LDD0209  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		C322(0.00); C762(0.00); C367(0.00); C789(0.00)  LDD0038  [2]
IA-alkyne
 Probe Info  		C322(0.00); C762(0.00); C367(0.00); C789(0.00)  LDD0036  [2]
IPIAA_H
 Probe Info  		C762(0.00); C610(0.00); C1072(0.00); C853(0.00)  LDD0030  [3]
IPIAA_L
 Probe Info  		C762(0.00); C1072(0.00); C1261(0.00); C400(0.00)  LDD0031  [3]
Lodoacetamide azide
 Probe Info  		C322(0.00); C762(0.00); C367(0.00); C789(0.00)  LDD0037  [2]
Compound 10
 Probe Info  		C1169(0.00); C1261(0.00); C610(0.00)  LDD2216  [4]
Compound 11
 Probe Info  		C1261(0.00); C610(0.00)  LDD2213  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C610(1.23); C1261(1.17); C1072(1.52)  LDD2187  [5]
 LDCM0572  Fragment10 Ramos C610(2.70); C1261(0.74); C1169(0.87); C1072(1.02)  LDD2189  [5]
 LDCM0573  Fragment11 Ramos C610(0.51); C1261(0.39); C1169(1.42); C762(20.00)  LDD2190  [5]
 LDCM0574  Fragment12 Ramos C610(2.27); C1261(0.79); C1169(1.03); C1072(0.93)  LDD2191  [5]
 LDCM0575  Fragment13 Ramos C610(1.07); C1261(0.97); C1169(1.34)  LDD2192  [5]
 LDCM0576  Fragment14 Ramos C610(1.44); C1261(0.74); C762(1.03); C1072(0.67)  LDD2193  [5]
 LDCM0579  Fragment20 Ramos C610(4.36); C1261(0.54); C1169(0.90); C1072(0.76)  LDD2194  [5]
 LDCM0580  Fragment21 Ramos C610(1.12); C1261(0.83); C1169(1.10)  LDD2195  [5]
 LDCM0582  Fragment23 Ramos C610(1.15); C1261(1.18); C1169(1.29)  LDD2196  [5]
 LDCM0578  Fragment27 Ramos C610(0.94); C1261(1.02); C1169(1.10)  LDD2197  [5]
 LDCM0586  Fragment28 Ramos C610(0.78); C1261(0.63); C1169(1.13); C762(0.49)  LDD2198  [5]
 LDCM0588  Fragment30 Ramos C610(1.34); C1261(1.38); C1169(0.83); C1072(1.24)  LDD2199  [5]
 LDCM0589  Fragment31 Ramos C610(1.06); C1261(0.87); C1169(1.61)  LDD2200  [5]
 LDCM0590  Fragment32 Ramos C610(3.37); C1261(1.12); C1169(0.84); C1072(0.98)  LDD2201  [5]
 LDCM0468  Fragment33 Ramos C610(1.37); C1261(0.95); C1169(0.96)  LDD2202  [5]
 LDCM0596  Fragment38 Ramos C610(1.20); C1261(1.18); C1169(1.11); C1072(1.92)  LDD2203  [5]
 LDCM0566  Fragment4 Ramos C610(1.62); C1261(0.68); C1072(0.92)  LDD2184  [5]
 LDCM0610  Fragment52 Ramos C610(1.22); C1261(1.31); C1169(1.38); C1072(1.55)  LDD2204  [5]
 LDCM0614  Fragment56 Ramos C610(1.03); C1261(1.16); C1169(1.34); C1072(0.97)  LDD2205  [5]
 LDCM0569  Fragment7 Ramos C610(1.56); C1261(0.65); C1072(0.78)  LDD2186  [5]
 LDCM0571  Fragment9 Ramos C610(3.11); C1261(0.55); C1169(1.14); C1072(0.70)  LDD2188  [5]
 LDCM0022  KB02 Ramos C610(2.10); C1261(1.00); C1072(0.66)  LDD2182  [5]
 LDCM0023  KB03 Jurkat C367(36.74)  LDD0209  [1]
 LDCM0024  KB05 MOLM-13 C754(2.44); C344(1.71); C1261(1.38)  LDD3333  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tyrosine-protein kinase CSK (CSK) Tyr protein kinase family P41240
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Receptor tyrosine-protein kinase erbB-2 (ERBB2) Tyr protein kinase family P04626
Tyrosine-protein kinase Lck (LCK) Tyr protein kinase family P06239
Angiopoietin-1 receptor (TEK) Tyr protein kinase family Q02763
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Integrin alpha-L (ITGAL) Integrin alpha chain family P20701
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Catenin beta-1 (CTNNB1) Beta-catenin family P35222
Galectin-1 (LGALS1) . P09382

The Drug(s) Related To This Target

Phase 3
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Iomab-b Antibody D08BBL
131i-labelled Acd45 Radiopharmaceutical therapy DC8EN0
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
[131i]-bc8 Antibody D0G5OE
Phase 1
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Anti-cd45 Mabs Antibody D0I0ZO
Iomab-act Antibody DZ7OC3
Lm-cd45 Antibody D06MMU
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Asp-brpmp-leu Small molecular drug D0N7VL
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ox-30 Antibody D0V4FP

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
4 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
5 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840