Details of the Target

General Information of Target

Target ID LDTP02194
Target Name Gamma-crystallin D (CRYGD)
Gene Name CRYGD
Gene ID 1421
Synonyms
CRYG4; Gamma-crystallin D; Gamma-D-crystallin; Gamma-crystallin 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGKITLYEDRGFQGRHYECSSDHPNLQPYLSRCNSARVDSGCWMLYEQPNYSGLQYFLRR
GDYADHQQWMGLSDSVRSCRLIPHSGSHRIRLYEREDYRGQMIEFTEDCSCLQDRFRFNE
IHSLNVLEGSWVLYELSNYRGRQYLLMPGDYRRYQDWGATNARVGSLRRVIDFS
Target Bioclass
Other
Family
Beta/gamma-crystallin family
Function Crystallins are the dominant structural components of the vertebrate eye lens.
Uniprot ID
P07320
Ensemble ID
ENST00000264376.5
HGNC ID
HGNC:2411
ChEMBL ID
CHEMBL4296286

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C111(1.03)  LDD0080  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0259  AC14 HEK-293T C111(0.93)  LDD1512  [2]
 LDCM0282  AC22 HEK-293T C111(1.02)  LDD1521  [2]
 LDCM0291  AC30 HEK-293T C111(1.00)  LDD1530  [2]
 LDCM0299  AC38 HEK-293T C111(0.96)  LDD1538  [2]
 LDCM0308  AC46 HEK-293T C111(1.19)  LDD1547  [2]
 LDCM0317  AC54 HEK-293T C111(0.99)  LDD1556  [2]
 LDCM0323  AC6 HEK-293T C111(1.10)  LDD1562  [2]
 LDCM0326  AC62 HEK-293T C111(0.79)  LDD1565  [2]
 LDCM0368  CL10 HEK-293T C111(0.76)  LDD1572  [2]
 LDCM0410  CL22 HEK-293T C111(0.96)  LDD1614  [2]
 LDCM0423  CL34 HEK-293T C111(0.95)  LDD1627  [2]
 LDCM0436  CL46 HEK-293T C111(0.80)  LDD1640  [2]
 LDCM0449  CL58 HEK-293T C111(0.91)  LDD1652  [2]
 LDCM0463  CL70 HEK-293T C111(0.94)  LDD1666  [2]
 LDCM0476  CL82 HEK-293T C111(0.74)  LDD1679  [2]
 LDCM0489  CL94 HEK-293T C111(0.89)  LDD1692  [2]
 LDCM0022  KB02 HCT 116 C111(1.03)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C111(1.06)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C111(0.93)  LDD0082  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402