Details of the Target

General Information of Target

Target ID LDTP02153
Target Name Protein S100-A6 (S100A6)
Gene Name S100A6
Gene ID 6277
Synonyms
CACY; Protein S100-A6; Calcyclin; Growth factor-inducible protein 2A9; MLN 4; Prolactin receptor-associated protein; PRA; S100 calcium-binding protein A6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MACPLDQAIGLLVAIFHKYSGREGDKHTLSKKELKELIQKELTIGSKLQDAEIARLMEDL
DRNKDQEVNFQEYVTFLGALALIYNEALKG
Target Type
Literature-reported
Target Bioclass
Other
Family
S-100 family
Subcellular location
Nucleus envelope
Function
May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.
TTD ID
T68513
Uniprot ID
P06703
DrugMap ID
TT716MY
Ensemble ID
ENST00000368719.9
HGNC ID
HGNC:10496

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		K26(0.28); K31(0.30); K35(0.42); K40(0.31)  LDD0274  [1]
STPyne
 Probe Info  		K26(8.67); K31(3.37); K32(6.46); K35(5.80)  LDD0277  [1]
OPA-S-S-alkyne
 Probe Info  		K47(6.35)  LDD3494  [2]
DBIA
 Probe Info  		C3(1.05)  LDD3337  [3]
m-APA
 Probe Info  		N.A.  LDD2231  [4]
CY-1
 Probe Info  		D50(0.00); E52(0.00); K47(0.00); S46(0.00)  LDD0246  [5]
ATP probe
 Probe Info  		K47(0.00); K31(0.00); K26(0.00)  LDD0035  [6]
AZ-9
 Probe Info  		N.A.  LDD0395  [7]
Acrolein
 Probe Info  		H17(0.00); H27(0.00)  LDD0217  [8]
Methacrolein
 Probe Info  		N.A.  LDD0218  [8]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]
HHS-465
 Probe Info  		K35(0.00); K47(0.00); K40(0.00)  LDD2240  [10]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
PARPYnD
 Probe Info  		1.59  LDD0375  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0146  AZ9482 MDA-MB-468 1.59  LDD0375  [11]
 LDCM0108  Chloroacetamide HeLa H27(0.00); H17(0.00)  LDD0222  [8]
 LDCM0107  IAA HeLa H17(0.00); H27(0.00)  LDD0221  [8]
 LDCM0022  KB02 COR-L88 C3(1.25)  LDD2311  [3]
 LDCM0023  KB03 COR-L88 C3(4.35)  LDD2728  [3]
 LDCM0024  KB05 MSTO-211H C3(1.05)  LDD3337  [3]
 LDCM0109  NEM HeLa N.A.  LDD0223  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase Mdm2 (MDM2) MDM2/MDM4 family Q00987
Myosin-9 (MYH9) Myosin family P35579
Calcyclin-binding protein (CACYBP) . Q9HB71
Peptidyl-prolyl cis-trans isomerase FKBP4 (FKBP4) . Q02790
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Importin subunit alpha-1 (KPNA2) Importin alpha family P52292
Cellular tumor antigen p53 (TP53) P53 family P04637
Protein S100-B (S100B) S-100 family P04271
Transient receptor potential cation channel subfamily M member 4 (TRPM4) Transient receptor (TC 1.A.4) family Q8TD43
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centrosomal protein 43 (CEP43) CEP43 family O95684
Protein FAM25C (FAM25C) FAM25 family B3EWG5
Peroxisomal targeting signal 1 receptor (PEX5) Peroxisomal targeting signal receptor family P50542

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Calcium Phosphate Small molecular drug DB11348
Calcium Phosphate Dihydrate Small molecular drug DB14481
Calcium Citrate . DB11093

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
6 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
7 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
11 Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for PARP Inhibitors. ACS Chem Biol. 2020 Feb 21;15(2):325-333. doi: 10.1021/acschembio.9b00963. Epub 2020 Feb 10.