Details of the Target

General Information of Target

Target ID LDTP02094
Target Name Myeloperoxidase (MPO)
Gene Name MPO
Gene ID 4353
Synonyms
Myeloperoxidase; MPO; EC 1.11.2.2) [Cleaved into: Myeloperoxidase; 89 kDa myeloperoxidase; 84 kDa myeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain]
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQPSEGAAPAVLGEVDTS
LVLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAVRAADYLH
VALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQDKYRTITGMC
NNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTD
QLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLKIPPND
PRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQL
GLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLL
REHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYR
SYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLE
GGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYN
AWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPL
LACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMS
NSYPRDFVNCSTLPALNLASWREAS
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Peroxidase family, XPO subfamily
Subcellular location
Lysosome
Function
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Mediates the proteolytic cleavage of alpha-1-microglobulin to form t-alpha-1-microglobulin, which potently inhibits oxidation of low-density lipoprotein particles and limits vascular damage.
TTD ID
T23471
Uniprot ID
P05164
DrugMap ID
TTVCZPI
Ensemble ID
ENST00000225275.4
HGNC ID
HGNC:7218
ChEMBL ID
CHEMBL2439

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8305C SNV: p.P269L .
CAL78 SNV: p.D264Y .
HCT15 SNV: p.K75N .
HEC1B SNV: p.V276I .
IM95 SNV: p.G212D .
MEWO SNV: p.G212D .
MOLT4 SNV: p.V279I .
NB1 SNV: p.G666V .
NCIH1155 SNV: p.A25V .
NCIH2291 SNV: p.Q696K .
SW756 SNV: p.S94I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C762(1.63); C736(2.70); C341(1.66)  LDD3333  [1]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 Kasumi-1 C762(1.56); C736(1.57); C430(1.24); C341(1.30)  LDD2414  [1]
 LDCM0023  KB03 Kasumi-1 C762(1.98); C736(2.12); C341(1.64)  LDD2831  [1]
 LDCM0024  KB05 MOLM-13 C762(1.63); C736(2.70); C341(1.66)  LDD3333  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase CHIP (STUB1) . Q9UNE7
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Properdin (CFP) . P27918

The Drug(s) Related To This Target

Approved
Click To Hide/Show 17 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Aminosalicylic Acid Small molecular drug DB00233
Bivalirudin Small molecular drug DB00006
Calcipotriol Small molecular drug DB02300
Capsaicin Small molecular drug DB06774
Cefaclor Small molecular drug DB00833
Cefdinir Small molecular drug DB00535
Cisplatin Small molecular drug DB00515
Cysteamine Small molecular drug DB00847
Dapsone Small molecular drug DB00250
Enoxaparin Small molecular drug DB01225
Levocarnitine Small molecular drug DB00583
Melatonin Small molecular drug DB01065
Nabumetone Small molecular drug DB00461
Nomifensine Small molecular drug DB04821
Propylthiouracil Small molecular drug DB00550
Ticlopidine Small molecular drug DB00208
Tolmetin Small molecular drug DB00500
Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
E-101 Small molecular drug D0XD5A
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Azd-3241 . D08TRG
Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Azd4831 . D07SBP
Investigative
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
4-aminobenzoic Acid Hydrazide Small molecular drug D05OZR
Cariporide Small molecular drug DB06468
Elafin . DB05161
Inv-311 . D01ZZG
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Azd5904 Small molecular drug D0Y3LJ

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.