Details of the Target

General Information of Target

Target ID LDTP01924
Target Name Collagen alpha-1(I) chain (COL1A1)
Gene Name COL1A1
Gene ID 1277
Synonyms
Collagen alpha-1(I) chain; Alpha-1 type I collagen
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRI
CVCDNGKVLCDDVICDETKNCPGAEVPEGECCPVCPDGSESPTDQETTGVEGPKGDTGPR
GPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGP
MGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGR
PGERGPPGPQGARGLPGTAGLPGMKGHRGFSGLDGAKGDAGPAGPKGEPGSPGENGAPGQ
MGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGP
RGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGP
QGPGGPPGPKGNSGEPGAPGSKGDTGAKGEPGPVGVQGPPGPAGEEGKRGARGEPGPTGL
PGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGL
TGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGV
PGPPGAVGPAGKDGEAGAQGPPGPAGPAGERGEQGPAGSPGFQGLPGPAGPPGEAGKPGE
QGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGS
QGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGD
KGESGPSGPAGPTGARGAPGDRGEPGPPGPAGFAGPPGADGQPGAKGEPGDAGAKGDAGP
PGPAGPAGPPGPIGNVGAPGAKGARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGP
AGKEGGKGPRGETGPAGRPGEVGPPGPPGPAGEKGSPGADGPAGAPGTPGPQGIAGQRGV
VGLPGQRGERGFPGLPGPSGEPGKQGPSGASGERGPPGPMGPPGLAGPPGESGREGAPGA
EGSPGRDGSPGAKGDRGETGPAGPPGAPGAPGAPGPVGPAGKSGDRGETGPAGPAGPVGP
VGARGPAGPQGPRGDKGETGEQGDRGIKGHRGFSGLQGPPGPPGSPGEQGPSGASGPAGP
RGPPGSAGAPGKDGLNGLPGPIGPPGPRGRTGDAGPVGPPGPPGPPGPPGPPSAGFDFSF
LPQPPQEKAHDGGRYYRADDANVVRDRDLEVDTTLKSLSQQIENIRSPEGSRKNPARTCR
DLKMCHSDWKSGEYWIDPNQGCNLDAIKVFCNMETGETCVYPTQPSVAQKNWYISKNPKD
KRHVWFGESMTDGFQFEYGGQGSDPADVAIQLTFLRLMSTEASQNITYHCKNSVAYMDQQ
TGNLKKALLLQGSNEIEIRAEGNSRFTYSVTVDGCTSHTGAWGKTVIEYKTTKTSRLPII
DVAPLDVGAPDQEFGFDVGPVCFL
Target Bioclass
Other
Family
Fibrillar collagen family
Subcellular location
Secreted, extracellular space, extracellular matrix
Function Type I collagen is a member of group I collagen (fibrillar forming collagen).
Uniprot ID
P02452
Ensemble ID
ENST00000225964.10
HGNC ID
HGNC:2197
ChEMBL ID
CHEMBL2364188

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1265(1.66)  LDD3310  [1]
N1
 Probe Info  		E1243(0.00); N1244(0.00); Q1241(0.00); R1246(0.00)  LDD0245  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C1282(0.78)  LDD1508  [3]
 LDCM0259  AC14 HEK-293T C1282(0.76)  LDD1512  [3]
 LDCM0277  AC18 HEK-293T C1282(1.17)  LDD1516  [3]
 LDCM0279  AC2 HEK-293T C1282(0.83)  LDD1518  [3]
 LDCM0281  AC21 HEK-293T C1282(1.14)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C1282(0.88)  LDD1521  [3]
 LDCM0286  AC26 HEK-293T C1282(0.98)  LDD1525  [3]
 LDCM0289  AC29 HEK-293T C1282(1.31)  LDD1528  [3]
 LDCM0291  AC30 HEK-293T C1282(0.77)  LDD1530  [3]
 LDCM0295  AC34 HEK-293T C1282(1.37)  LDD1534  [3]
 LDCM0298  AC37 HEK-293T C1282(1.10)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C1282(0.73)  LDD1538  [3]
 LDCM0304  AC42 HEK-293T C1282(0.92)  LDD1543  [3]
 LDCM0307  AC45 HEK-293T C1282(1.10)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C1282(0.79)  LDD1547  [3]
 LDCM0312  AC5 HEK-293T C1282(1.14)  LDD1551  [3]
 LDCM0313  AC50 HEK-293T C1282(1.27)  LDD1552  [3]
 LDCM0316  AC53 HEK-293T C1282(0.88)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C1282(0.89)  LDD1556  [3]
 LDCM0321  AC58 HEK-293T C1282(1.11)  LDD1560  [3]
 LDCM0323  AC6 HEK-293T C1282(0.89)  LDD1562  [3]
 LDCM0325  AC61 HEK-293T C1282(0.86)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C1282(0.82)  LDD1565  [3]
 LDCM0248  AKOS034007472 HEK-293T C1282(1.08)  LDD1511  [3]
 LDCM0367  CL1 HEK-293T C1282(1.02)  LDD1571  [3]
 LDCM0368  CL10 HEK-293T C1282(0.88)  LDD1572  [3]
 LDCM0370  CL101 HEK-293T C1282(0.87)  LDD1574  [3]
 LDCM0374  CL105 HEK-293T C1282(1.07)  LDD1578  [3]
 LDCM0378  CL109 HEK-293T C1282(1.69)  LDD1582  [3]
 LDCM0383  CL113 HEK-293T C1282(1.23)  LDD1587  [3]
 LDCM0387  CL117 HEK-293T C1282(0.99)  LDD1591  [3]
 LDCM0392  CL121 HEK-293T C1282(1.23)  LDD1596  [3]
 LDCM0396  CL125 HEK-293T C1282(1.06)  LDD1600  [3]
 LDCM0400  CL13 HEK-293T C1282(0.85)  LDD1604  [3]
 LDCM0405  CL18 HEK-293T C1282(1.03)  LDD1609  [3]
 LDCM0409  CL21 HEK-293T C1282(0.78)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C1282(1.31)  LDD1614  [3]
 LDCM0413  CL25 HEK-293T C1282(0.97)  LDD1617  [3]
 LDCM0419  CL30 HEK-293T C1282(1.05)  LDD1623  [3]
 LDCM0422  CL33 HEK-293T C1282(0.71)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C1282(1.04)  LDD1627  [3]
 LDCM0426  CL37 HEK-293T C1282(1.06)  LDD1630  [3]
 LDCM0432  CL42 HEK-293T C1282(1.05)  LDD1636  [3]
 LDCM0435  CL45 HEK-293T C1282(0.97)  LDD1639  [3]
 LDCM0436  CL46 HEK-293T C1282(1.08)  LDD1640  [3]
 LDCM0439  CL49 HEK-293T C1282(0.99)  LDD1643  [3]
 LDCM0445  CL54 HEK-293T C1282(1.68)  LDD1648  [3]
 LDCM0448  CL57 HEK-293T C1282(1.30)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C1282(0.99)  LDD1652  [3]
 LDCM0451  CL6 HEK-293T C1282(1.25)  LDD1654  [3]
 LDCM0453  CL61 HEK-293T C1282(0.75)  LDD1656  [3]
 LDCM0458  CL66 HEK-293T C1282(1.16)  LDD1661  [3]
 LDCM0461  CL69 HEK-293T C1282(1.25)  LDD1664  [3]
 LDCM0463  CL70 HEK-293T C1282(0.76)  LDD1666  [3]
 LDCM0466  CL73 HEK-293T C1282(0.72)  LDD1669  [3]
 LDCM0471  CL78 HEK-293T C1282(1.25)  LDD1674  [3]
 LDCM0475  CL81 HEK-293T C1282(0.79)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C1282(0.88)  LDD1679  [3]
 LDCM0479  CL85 HEK-293T C1282(0.81)  LDD1682  [3]
 LDCM0484  CL9 HEK-293T C1282(0.69)  LDD1687  [3]
 LDCM0485  CL90 HEK-293T C1282(1.23)  LDD1688  [3]
 LDCM0488  CL93 HEK-293T C1282(0.89)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C1282(0.75)  LDD1692  [3]
 LDCM0492  CL97 HEK-293T C1282(0.80)  LDD1695  [3]
 LDCM0022  KB02 42-MG-BA C1265(1.55); C1282(1.35)  LDD2244  [1]
 LDCM0023  KB03 42-MG-BA C1282(1.34)  LDD2661  [1]
 LDCM0024  KB05 COLO792 C1265(1.66)  LDD3310  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Collagen alpha-2(I) chain (COL1A2) Fibrillar collagen family P08123
Kelch-like ECH-associated protein 1 (KEAP1) KEAP1 family Q14145
Fibronectin (FN1) . P02751

The Drug(s) Related To This Target

Approved
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Collagenase Clostridium Histolyticum BiotechDrug DB00048
Clove Oil . DB11338
Von Willebrand Factor Human . DB13133
Vonicog Alfa . DB12872
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Halofuginone . DB04866

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402