Details of the Target

General Information of Target

Target ID LDTP01855
Target Name Pro-neuropeptide Y (NPY)
Gene Name NPY
Gene ID 4852
Synonyms
Pro-neuropeptide Y [Cleaved into: Neuropeptide Y; Neuropeptide tyrosine; NPY; C-flanking peptide of NPY; CPON)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLGNKRLGLSGLTLALSLLVCLGALAEAYPSKPDNPGEDAPAEDMARYYSALRHYINLIT
RQRYGKRSSPETLISDLLMRESTENVPRTRLEDPAMW
Target Type
Literature-reported
Target Bioclass
Other
Family
NPY family
Subcellular location
Secreted
Function NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
TTD ID
T51671
Uniprot ID
P01303
DrugMap ID
TT64REZ
Ensemble ID
ENST00000242152.7
HGNC ID
HGNC:7955

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		62.80  LDD0318  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquilin-2 (UBQLN2) . Q9UHD9

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Phentermine Small molecular drug DB00191
Investigative
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
2-aminoisobutyric Acid Small molecular drug DB02952
Alpha-aminoisobutyric Acid Small molecular drug D08JUG
L-tyrosinamide Small molecular drug D0DO9W
L-tyrosinamide Small molecular drug DB03380

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580