Details of the Target

General Information of Target

Target ID LDTP01819
Target Name Cystatin-S (CST4)
Gene Name CST4
Gene ID 1472
Synonyms
Cystatin-S; Cystatin-4; Cystatin-SA-III; Salivary acidic protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MARPLCTLLLLMATLAGALASSSKEENRIIPGGIYDADLNDEWVQRALHFAISEYNKATE
DEYYRRPLQVLRAREQTFGGVNYFFDVEVGRTICTKSQPNLDTCAFHEQPELQKKQLCSF
EIYEVPWEDRMSLVNSRCQEA
Target Bioclass
Other
Family
Cystatin family
Subcellular location
Secreted
Function
This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non-competitively.
Uniprot ID
P01036
Ensemble ID
ENST00000217423.4
HGNC ID
HGNC:2476

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TPP-AC
 Probe Info  		N.A.  LDD0427  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquilin-2 (UBQLN2) . Q9UHD9

References

1 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.