Details of the Target

General Information of Target

Target ID LDTP01668
Target Name Semaphorin-4F (SEMA4F)
Gene Name SEMA4F
Gene ID 10505
Synonyms
SEMAM; SEMAW; Semaphorin-4F; Semaphorin-M; Sema M; Semaphorin-W; Sema W
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPASAARPRPGPGQPTASPFPLLLLAVLSGPVSGRVPRSVPRTSLPISEADSCLTRFAVP
HTYNYSVLLVDPASHTLYVGARDTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGKKED
ECHNFVQILAIANASHLLTCGTFAFDPKCGVIDVSRFQQVERLESGRGKCPFEPAQRSAA
VMAGGVLYAATVKNYLGTEPIITRAVGRAEDWIRTDTLPSWLNAPAFVAAVALSPAEWGD
EDGDDEIYFFFTETSRAFDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCPGP
EHGRASSVLQDVAVLRPELGAGTPIFYGIFSSQWEGATISAVCAFRPQDIRTVLNGPFRE
LKHDCNRGLPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDRPVFP
ADGHPLLVTTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQLSVLEDLAL
FPEPQPVENMKLYHSWLLVGSRTEVTQVNTTNCGRLQSCSECILAQDPVCAWSFRLDECV
AHAGEHRGLVQDIESADVSSLCPKEPGERPVVFEVPVATAAHVVLPCSPSSAWASCVWHQ
PSGVTALTPRRDGLEVVVTPGAMGAYACECQEGGAAHVVAAYSLVWGSQRDAPSRAHTVG
AGLAGFFLGILAASLTLILIGRRQQRRRQRELLARDKVGLDLGAPPSGTTSYSQDPPSPS
PEDERLPLALAKRGSGFGGFSPPFLLDPCPSPAHIRLTGAPLATCDETSI
Target Bioclass
Other
Family
Semaphorin family
Subcellular location
Cell membrane
Function
Probable cell surface receptor that regulates oligodendroglial precursor cell migration. Might also regulate differentiation of oligodendroglial precursor cells. Has growth cone collapse activity against retinal ganglion-cell axons.
Uniprot ID
O95754
Ensemble ID
ENST00000339773.9
HGNC ID
HGNC:10734

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA Insertion: p.R610PfsTer20 .
BICR22 SNV: p.A5S .
COLO792 SNV: p.L24M .
JURKAT SNV: p.Q600Ter .
KASUMI2 SNV: p.F143V .
KU1919 SNV: p.R208C .
LS180 SNV: p.V154M .
MDAMB436 SNV: p.F251V .
MFE319 Insertion: p.R610PfsTer20 .
MOLT4 Deletion: p.A661RfsTer15 .
NUGC3 SNV: p.P563S .
OVK18 Deletion: p.R610GfsTer9 .
SW1116 SNV: p.T16P; p.A17D .
SW756 SNV: p.L671F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C273(1.16); C384(0.97)  LDD1513  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0270  AC15 HEK-293T C273(1.16); C384(0.97)  LDD1513  [1]
 LDCM0283  AC23 HEK-293T C273(0.99); C384(0.99)  LDD1522  [1]
 LDCM0292  AC31 HEK-293T C273(0.94); C384(1.06)  LDD1531  [1]
 LDCM0300  AC39 HEK-293T C273(1.02); C384(1.02)  LDD1539  [1]
 LDCM0309  AC47 HEK-293T C273(0.92); C384(1.06)  LDD1548  [1]
 LDCM0318  AC55 HEK-293T C273(0.94); C384(1.13)  LDD1557  [1]
 LDCM0327  AC63 HEK-293T C273(0.92); C384(0.99)  LDD1566  [1]
 LDCM0334  AC7 HEK-293T C273(1.21); C384(1.06)  LDD1568  [1]
 LDCM0379  CL11 HEK-293T C273(0.92); C384(1.13)  LDD1583  [1]
 LDCM0411  CL23 HEK-293T C273(1.00); C384(1.36)  LDD1615  [1]
 LDCM0424  CL35 HEK-293T C273(0.91); C384(1.31)  LDD1628  [1]
 LDCM0437  CL47 HEK-293T C273(0.98); C384(1.14)  LDD1641  [1]
 LDCM0450  CL59 HEK-293T C273(0.95); C384(1.13)  LDD1653  [1]
 LDCM0464  CL71 HEK-293T C273(0.92); C384(1.30)  LDD1667  [1]
 LDCM0477  CL83 HEK-293T C273(0.82); C384(1.16)  LDD1680  [1]
 LDCM0490  CL95 HEK-293T C273(0.87); C384(1.13)  LDD1693  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402