Details of the Target

General Information of Target

Target ID LDTP01446
Target Name Transmembrane and coiled-coil domains protein 1 (TMCC1)
Gene Name TMCC1
Gene ID 23023
Synonyms
KIAA0779; Transmembrane and coiled-coil domains protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPSGSEQLFEDPDPGGKSQDAEARKQTESEQKLSKMTHNALENINVIGQGLKHLFQHQR
RRSSVSPHDVQQIQADPEPEMDLESQNACAEIDGVPTHPTALNRVLQQIRVPPKMKRGTS
LHSRRGKPEAPKGSPQINRKSGQEMTAVMQSGRPRSSSTTDAPTSSAMMEIACAAAAAAA
ACLPGEEGTAERIERLEVSSLAQTSSAVASSTDGSIHTDSVDGTPDPQRTKAAIAHLQQK
ILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIKQVFEKKNQKSAQTILQLQKKLE
HYHRKLREVEQNGIPRQPKDVFRDMHQGLKDVGAKVTGFSEGVVDSVKGGFSSFSQATHS
AAGAVVSKPREIASLIRNKFGSADNIPNLKDSLEEGQVDDAGKALGVISNFQSSPKYGSE
EDCSSATSGSVGANSTTGGIAVGASSSKTNTLDMQSSGFDALLHEIQEIRETQARLEESF
ETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQ
SYERARDIQEALEACQTRISKMELQQQQQQVVQLEGLENATARNLLGKLINILLAVMAVL
LVFVSTVANCVVPLMKTRNRTFSTLFLVVFIAFLWKHWDALFSYVERFFSSPR
Target Bioclass
Transporter and channel
Family
TEX28 family
Subcellular location
Endoplasmic reticulum membrane
Function
Endoplasmic reticulum membrane protein that promotes endoplasmic reticulum-associated endosome fission. Localizes to contact sites between the endoplasmic reticulum and endosomes and acts by promoting recruitment of the endoplasmic reticulum to endosome tubules for fission. Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane.
Uniprot ID
O94876
Ensemble ID
ENST00000393238.8
HGNC ID
HGNC:29116

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.G363S .
HCC827 SNV: p.Q59H .
KMCH1 SNV: p.A582S .
MDAMB157 Deletion: p.R475SfsTer2 .
MEWO SNV: p.E500K .
MOLT4 SNV: p.R502Ter .
NCIH1299 SNV: p.K264R .
SW756 SNV: p.E535Ter .
UMUC3 SNV: p.E282Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		H54(0.00); H58(0.00)  LDD0223  [1]
DBIA
 Probe Info  		C555(1.15)  LDD1492  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C555(0.97)  LDD1508  [2]
 LDCM0226  AC11 HEK-293T C555(0.89)  LDD1509  [2]
 LDCM0259  AC14 HEK-293T C555(0.91)  LDD1512  [2]
 LDCM0277  AC18 HEK-293T C555(1.09)  LDD1516  [2]
 LDCM0278  AC19 HEK-293T C555(0.91)  LDD1517  [2]
 LDCM0279  AC2 HEK-293T C555(0.99)  LDD1518  [2]
 LDCM0281  AC21 HEK-293T C555(1.07)  LDD1520  [2]
 LDCM0282  AC22 HEK-293T C555(1.12)  LDD1521  [2]
 LDCM0286  AC26 HEK-293T C555(1.02)  LDD1525  [2]
 LDCM0287  AC27 HEK-293T C555(0.84)  LDD1526  [2]
 LDCM0289  AC29 HEK-293T C555(0.73)  LDD1528  [2]
 LDCM0290  AC3 HEK-293T C555(0.87)  LDD1529  [2]
 LDCM0291  AC30 HEK-293T C555(1.00)  LDD1530  [2]
 LDCM0295  AC34 HEK-293T C555(0.98)  LDD1534  [2]
 LDCM0296  AC35 HEK-293T C555(1.02)  LDD1535  [2]
 LDCM0298  AC37 HEK-293T C555(0.79)  LDD1537  [2]
 LDCM0299  AC38 HEK-293T C555(1.01)  LDD1538  [2]
 LDCM0304  AC42 HEK-293T C555(0.93)  LDD1543  [2]
 LDCM0305  AC43 HEK-293T C555(0.85)  LDD1544  [2]
 LDCM0307  AC45 HEK-293T C555(0.81)  LDD1546  [2]
 LDCM0308  AC46 HEK-293T C555(1.46)  LDD1547  [2]
 LDCM0312  AC5 HEK-293T C555(1.09)  LDD1551  [2]
 LDCM0313  AC50 HEK-293T C555(1.09)  LDD1552  [2]
 LDCM0314  AC51 HEK-293T C555(0.91)  LDD1553  [2]
 LDCM0316  AC53 HEK-293T C555(0.99)  LDD1555  [2]
 LDCM0317  AC54 HEK-293T C555(0.93)  LDD1556  [2]
 LDCM0321  AC58 HEK-293T C555(0.99)  LDD1560  [2]
 LDCM0322  AC59 HEK-293T C555(0.90)  LDD1561  [2]
 LDCM0323  AC6 HEK-293T C555(1.11)  LDD1562  [2]
 LDCM0325  AC61 HEK-293T C555(1.06)  LDD1564  [2]
 LDCM0326  AC62 HEK-293T C555(0.95)  LDD1565  [2]
 LDCM0248  AKOS034007472 HEK-293T C555(0.99)  LDD1511  [2]
 LDCM0367  CL1 HEK-293T C555(1.29)  LDD1571  [2]
 LDCM0368  CL10 HEK-293T C555(1.24)  LDD1572  [2]
 LDCM0370  CL101 HEK-293T C555(1.13)  LDD1574  [2]
 LDCM0374  CL105 HEK-293T C555(1.06)  LDD1578  [2]
 LDCM0378  CL109 HEK-293T C555(1.05)  LDD1582  [2]
 LDCM0383  CL113 HEK-293T C555(0.96)  LDD1587  [2]
 LDCM0387  CL117 HEK-293T C555(1.29)  LDD1591  [2]
 LDCM0392  CL121 HEK-293T C555(1.07)  LDD1596  [2]
 LDCM0396  CL125 HEK-293T C555(0.94)  LDD1600  [2]
 LDCM0400  CL13 HEK-293T C555(0.79)  LDD1604  [2]
 LDCM0405  CL18 HEK-293T C555(1.15)  LDD1609  [2]
 LDCM0406  CL19 HEK-293T C555(1.00)  LDD1610  [2]
 LDCM0409  CL21 HEK-293T C555(1.09)  LDD1613  [2]
 LDCM0410  CL22 HEK-293T C555(1.03)  LDD1614  [2]
 LDCM0413  CL25 HEK-293T C555(1.14)  LDD1617  [2]
 LDCM0419  CL30 HEK-293T C555(0.97)  LDD1623  [2]
 LDCM0420  CL31 HEK-293T C555(0.98)  LDD1624  [2]
 LDCM0422  CL33 HEK-293T C555(1.57)  LDD1626  [2]
 LDCM0423  CL34 HEK-293T C555(1.10)  LDD1627  [2]
 LDCM0426  CL37 HEK-293T C555(1.02)  LDD1630  [2]
 LDCM0432  CL42 HEK-293T C555(1.06)  LDD1636  [2]
 LDCM0433  CL43 HEK-293T C555(0.87)  LDD1637  [2]
 LDCM0435  CL45 HEK-293T C555(0.94)  LDD1639  [2]
 LDCM0436  CL46 HEK-293T C555(0.78)  LDD1640  [2]
 LDCM0439  CL49 HEK-293T C555(1.00)  LDD1643  [2]
 LDCM0445  CL54 HEK-293T C555(0.98)  LDD1648  [2]
 LDCM0446  CL55 HEK-293T C555(0.95)  LDD1649  [2]
 LDCM0448  CL57 HEK-293T C555(0.87)  LDD1651  [2]
 LDCM0449  CL58 HEK-293T C555(0.94)  LDD1652  [2]
 LDCM0451  CL6 HEK-293T C555(1.18)  LDD1654  [2]
 LDCM0453  CL61 HEK-293T C555(0.85)  LDD1656  [2]
 LDCM0458  CL66 HEK-293T C555(1.01)  LDD1661  [2]
 LDCM0459  CL67 HEK-293T C555(0.89)  LDD1662  [2]
 LDCM0461  CL69 HEK-293T C555(0.93)  LDD1664  [2]
 LDCM0462  CL7 HEK-293T C555(0.91)  LDD1665  [2]
 LDCM0463  CL70 HEK-293T C555(0.89)  LDD1666  [2]
 LDCM0466  CL73 HEK-293T C555(1.14)  LDD1669  [2]
 LDCM0471  CL78 HEK-293T C555(0.97)  LDD1674  [2]
 LDCM0472  CL79 HEK-293T C555(0.85)  LDD1675  [2]
 LDCM0475  CL81 HEK-293T C555(1.08)  LDD1678  [2]
 LDCM0476  CL82 HEK-293T C555(1.04)  LDD1679  [2]
 LDCM0479  CL85 HEK-293T C555(0.87)  LDD1682  [2]
 LDCM0484  CL9 HEK-293T C555(1.22)  LDD1687  [2]
 LDCM0485  CL90 HEK-293T C555(1.00)  LDD1688  [2]
 LDCM0486  CL91 HEK-293T C555(0.90)  LDD1689  [2]
 LDCM0488  CL93 HEK-293T C555(0.94)  LDD1691  [2]
 LDCM0489  CL94 HEK-293T C555(1.24)  LDD1692  [2]
 LDCM0492  CL97 HEK-293T C555(2.01)  LDD1695  [2]
 LDCM0022  KB02 HEK-293T C555(1.15)  LDD1492  [2]
 LDCM0023  KB03 HEK-293T C555(1.04)  LDD1497  [2]
 LDCM0024  KB05 HEK-293T C555(1.23)  LDD1502  [2]
 LDCM0109  NEM HeLa H54(0.00); H58(0.00)  LDD0223  [1]

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402