Details of the Target

General Information of Target

Target ID LDTP01367
Target Name Cyclin-dependent kinase 2-associated protein 2 (CDK2AP2)
Gene Name CDK2AP2
Gene ID 10263
Synonyms
DOC1R; Cyclin-dependent kinase 2-associated protein 2; CDK2-associated protein 2; DOC-1-related protein; DOC-1R
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSYKPIAPAPSSTPGSSTPGPGTPVPTGSVPSPSGSVPGAGAPFRPLFNDFGPPSMGYVQ
AMKPPGAQGSQSTYTDLLSVIEEMGKEIRPTYAGSKSAMERLKRGIIHARALVRECLAET
ERNART
Target Bioclass
Other
Family
CDK2AP family
Subcellular location
Cytoplasm
Function
Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation; represses CDK2 activation by inhibiting its interaction with cyclin E and A. Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs. Regulates microtubule organization of metaphase II oocytes.
Uniprot ID
O75956
Ensemble ID
ENST00000301488.8
HGNC ID
HGNC:30833
ChEMBL ID
CHEMBL6010

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C116(3.30)  LDD1699  [1]
DBIA
 Probe Info  		C77(4.65)  LDD3331  [2]
Acrolein
 Probe Info  		C116(0.00); H108(0.00)  LDD0222  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [4]
IPM
 Probe Info  		N.A.  LDD0025  [5]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [5]
TFBX
 Probe Info  		N.A.  LDD0027  [5]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [6]
Methacrolein
 Probe Info  		N.A.  LDD0218  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C116(0.49)  LDD2142  [1]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C116(0.78)  LDD2112  [1]
 LDCM0226  AC11 HEK-293T C116(1.07)  LDD1509  [7]
 LDCM0278  AC19 HEK-293T C116(0.94)  LDD1517  [7]
 LDCM0287  AC27 HEK-293T C116(0.97)  LDD1526  [7]
 LDCM0290  AC3 HEK-293T C116(0.90)  LDD1529  [7]
 LDCM0296  AC35 HEK-293T C116(1.15)  LDD1535  [7]
 LDCM0305  AC43 HEK-293T C116(1.23)  LDD1544  [7]
 LDCM0314  AC51 HEK-293T C116(1.21)  LDD1553  [7]
 LDCM0322  AC59 HEK-293T C116(1.15)  LDD1561  [7]
 LDCM0108  Chloroacetamide HeLa C116(0.00); H108(0.00)  LDD0222  [3]
 LDCM0367  CL1 HEK-293T C116(0.80)  LDD1571  [7]
 LDCM0369  CL100 HEK-293T C116(1.09)  LDD1573  [7]
 LDCM0370  CL101 HEK-293T C116(1.03)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C116(1.11)  LDD1575  [7]
 LDCM0373  CL104 HEK-293T C116(1.06)  LDD1577  [7]
 LDCM0374  CL105 HEK-293T C116(1.03)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C116(1.02)  LDD1579  [7]
 LDCM0377  CL108 HEK-293T C116(1.20)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C116(0.90)  LDD1582  [7]
 LDCM0380  CL110 HEK-293T C116(0.90)  LDD1584  [7]
 LDCM0382  CL112 HEK-293T C116(0.90)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C116(1.10)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C116(1.05)  LDD1588  [7]
 LDCM0386  CL116 HEK-293T C116(1.20)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C116(1.13)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C116(1.02)  LDD1592  [7]
 LDCM0391  CL120 HEK-293T C116(1.11)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C116(1.13)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C116(1.14)  LDD1597  [7]
 LDCM0395  CL124 HEK-293T C116(1.13)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C116(0.92)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C116(1.02)  LDD1601  [7]
 LDCM0399  CL128 HEK-293T C116(1.09)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C116(0.91)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C116(1.13)  LDD1605  [7]
 LDCM0403  CL16 HEK-293T C116(1.16)  LDD1607  [7]
 LDCM0406  CL19 HEK-293T C116(1.16)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C116(1.11)  LDD1611  [7]
 LDCM0413  CL25 HEK-293T C116(1.01)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C116(1.31)  LDD1618  [7]
 LDCM0416  CL28 HEK-293T C116(1.13)  LDD1620  [7]
 LDCM0420  CL31 HEK-293T C116(1.11)  LDD1624  [7]
 LDCM0426  CL37 HEK-293T C116(1.20)  LDD1630  [7]
 LDCM0429  CL4 HEK-293T C116(1.09)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C116(1.27)  LDD1634  [7]
 LDCM0433  CL43 HEK-293T C116(1.16)  LDD1637  [7]
 LDCM0439  CL49 HEK-293T C116(0.93)  LDD1643  [7]
 LDCM0441  CL50 HEK-293T C116(1.13)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C116(1.03)  LDD1646  [7]
 LDCM0446  CL55 HEK-293T C116(1.20)  LDD1649  [7]
 LDCM0453  CL61 HEK-293T C116(1.10)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C116(1.16)  LDD1657  [7]
 LDCM0456  CL64 HEK-293T C116(1.13)  LDD1659  [7]
 LDCM0459  CL67 HEK-293T C116(1.16)  LDD1662  [7]
 LDCM0462  CL7 HEK-293T C116(1.10)  LDD1665  [7]
 LDCM0466  CL73 HEK-293T C116(0.90)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C116(1.01)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C116(1.11)  LDD1672  [7]
 LDCM0472  CL79 HEK-293T C116(1.00)  LDD1675  [7]
 LDCM0479  CL85 HEK-293T C116(1.07)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C116(1.06)  LDD1683  [7]
 LDCM0482  CL88 HEK-293T C116(1.36)  LDD1685  [7]
 LDCM0486  CL91 HEK-293T C116(1.10)  LDD1689  [7]
 LDCM0492  CL97 HEK-293T C116(0.88)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C116(0.92)  LDD1696  [7]
 LDCM0427  Fragment51 HEK-293T C116(1.10)  LDD1631  [7]
 LDCM0022  KB02 HEK-293T C116(0.90)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C116(0.97)  LDD1497  [7]
 LDCM0024  KB05 MKN-1 C77(4.65)  LDD3331  [2]
 LDCM0109  NEM HeLa N.A.  LDD0223  [3]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C116(0.55)  LDD2100  [1]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C116(0.30)  LDD2115  [1]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C116(0.74)  LDD2141  [1]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C116(0.35)  LDD2148  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MORF4 family-associated protein 1-like 1 (MRFAP1L1) MORF4 family-associated protein family Q96HT8

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402