Details of the Target
General Information of Target
| Target ID | LDTP01069 | |||||
|---|---|---|---|---|---|---|
| Target Name | Protein diaphanous homolog 2 (DIAPH2) |
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| Gene Name | DIAPH2 | |||||
| Gene ID | 1730 | |||||
| Synonyms |
DIA; Protein diaphanous homolog 2; Diaphanous-related formin-2; DRF2 |
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| 3D Structure | ||||||
| Sequence |
MEQPGAAASGAGGGSEEPGGGRSNKRSAGNRAANEEETKNKPKLNIQIKTLADDVRDRIT
SFRKSTVKKEKPLIQHPIDSQVAMSEFPAAQPLYDERSLNLSEKEVLDLFEKMMEDMNLN EEKKAPLRNKDFTTKREMVVQYISATAKSGGLKNSKHECTLSSQEYVHELRSGISDEKLL NCLESLRVSLTSNPVSWVNNFGHEGLGLLLDELEKLLDKKQQENIDKKNQYKLIQCLKAF MNNKFGLQRILGDERSLLLLARAIDPKQPNMMTEIVKILSAICIVGEENILDKLLGAITT AAERNNRERFSPIVEGLENQEALQLQVACMQFINALVTSPYELDFRIHLRNEFLRSGLKT MLPDLKEKENDELDIQLKVFDENKEDDLTELSHRLNDIRAEMDDMNEVYHLLYNMLKDTA AENYFLSILQHFLLIRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQRLDIDLTHL IDSCVNKAKVEESEQKAAEFSKKFDEEFTARQEAQAELQKRDEKIKELEAEIQQLRTQAQ VLSSSSGIPGPPAAPPLPGVGPPPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPPPLLF GGPPPPPPLGGVPPPPGISLNLPYGMKQKKMYKPEVSMKRINWSKIEPTELSENCFWLRV KEDKFENPDLFAKLALNFATQIKVQKNAEALEEKKTGPTKKKVKELRILDPKTAQNLSIF LGSYRMPYEDIRNVILEVNEDMLSEALIQNLVKHLPEQKILNELAELKNEYDDLCEPEQF GVVMSSVKMLQPRLSSILFKLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLV GNYMNSGSRNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEKYRDILKFPEELEH VESASKVSAQILKSNLASMEQQIVHLERDIKKFPQAENQHDKFVEKMTSFTKTAREQYEK LSTMHNNMMKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRREMEEKTR RAKLAKEKAEQEKLERQKKKKQLIDINKEGDETGVMDNLLEALQSGAAFRDRRKRIPRNP DNRRVPLERSRSRHNGAISSK |
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| Target Bioclass |
Other
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| Family |
Formin homology family, Diaphanous subfamily
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| Subcellular location |
Cytoplasm, cytosol
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| Function |
Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| A431 | Substitution: p.G246F | . | |||
| EGI1 | SNV: p.S829R | DBIA Probe Info | |||
| HT | SNV: p.E527Ter | . | |||
| ICC9 | SNV: p.Q248P | . | |||
| KARPAS422 | SNV: p.F245L | . | |||
| KYSE510 | SNV: p.Q515Ter | . | |||
| MCC13 | SNV: p.P583S | . | |||
| MFE319 | Insertion: p.N100AfsTer6 | . | |||
| NCIH2122 | SNV: p.E86D | . | |||
| NCIH2286 | Deletion: p.G602DfsTer25 | . | |||
| ONS76 | SNV: p.R725H | . | |||
| OVK18 | SNV: p.P668S | . | |||
| SW837 | SNV: p.E121K | DBIA Probe Info | |||
| TFK1 | SNV: p.P812A | . | |||
| UACC62 | SNV: p.P556L | DBIA Probe Info | |||
| YSCCC | SNV: p.E1032Q | . | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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STPyne Probe Info |
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K503(2.95) | LDD0277 | [1] | |
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BTD Probe Info |
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C182(0.60) | LDD2109 | [2] | |
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DA-P3 Probe Info |
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4.24 | LDD0183 | [3] | |
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DBIA Probe Info |
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C775(1.20) | LDD0080 | [4] | |
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4-Iodoacetamidophenylacetylene Probe Info |
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C159(0.00); C655(0.00); C775(0.00); C484(0.00) | LDD0038 | [5] | |
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IA-alkyne Probe Info |
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C655(0.00); C775(0.00); C283(0.00); C182(0.00) | LDD0036 | [5] | |
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Lodoacetamide azide Probe Info |
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C655(0.00); C775(0.00); C283(0.00); C484(0.00) | LDD0037 | [5] | |
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NAIA_5 Probe Info |
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C159(0.00); C484(0.00) | LDD2224 | [6] | |
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WYneN Probe Info |
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N.A. | LDD0021 | [7] | |
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IPM Probe Info |
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N.A. | LDD0005 | [7] | |
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Acrolein Probe Info |
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N.A. | LDD0217 | [8] | |
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W1 Probe Info |
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N.A. | LDD0236 | [9] | |
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AOyne Probe Info |
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7.70 | LDD0443 | [10] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0524 | 2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide | MDA-MB-231 | C182(1.07) | LDD2117 | [2] |
| LDCM0108 | Chloroacetamide | HeLa | C484(0.00); C182(0.00); C159(0.00) | LDD0222 | [8] |
| LDCM0632 | CL-Sc | Hep-G2 | C159(1.20) | LDD2227 | [6] |
| LDCM0031 | Epigallocatechin gallate | HEK-293T | 4.24 | LDD0183 | [3] |
| LDCM0107 | IAA | HeLa | C182(0.00); K686(0.00) | LDD0221 | [8] |
| LDCM0022 | KB02 | HCT 116 | C775(1.20) | LDD0080 | [4] |
| LDCM0023 | KB03 | HCT 116 | C775(1.52) | LDD0081 | [4] |
| LDCM0024 | KB05 | HCT 116 | C775(1.25) | LDD0082 | [4] |
| LDCM0516 | Nucleophilic fragment 21a | MDA-MB-231 | C182(0.60) | LDD2109 | [2] |
| LDCM0530 | Nucleophilic fragment 28a | MDA-MB-231 | C182(1.12) | LDD2123 | [2] |
| LDCM0543 | Nucleophilic fragment 38 | MDA-MB-231 | C182(1.23) | LDD2136 | [2] |
| LDCM0550 | Nucleophilic fragment 5a | MDA-MB-231 | C862(1.58) | LDD2144 | [2] |
References