Details of the Target

General Information of Target

Target ID LDTP01045
Target Name Cytohesin-interacting protein (CYTIP)
Gene Name CYTIP
Gene ID 9595
Synonyms
PSCDBP; Cytohesin-interacting protein; Cytohesin binder and regulator; CYBR; Cytohesin-associated scaffolding protein; CASP; Cytohesin-binding protein HE; Cbp HE; Pleckstrin homology Sec7 and coiled-coil domains-binding protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSLQRLLQHSSNGNLADFCAGPAYSSYSTLTGSLTMDDNRRIQMLADTVATLPRGRKQLA
LTRSSSLSDFSWSQRKLVTVEKQDNETFGFEIQSYRPQNQNACSSEMFTLICKIQEDSPA
HCAGLQAGDVLANINGVSTEGFTYKQVVDLIRSSGNLLTIETLNGTMILKRTELEAKLQV
LKQTLKQKWVEYRSLQLQEHRLLHGDAANCPSLENMDLDELSLFGPLPGPGPALVDRNRL
SSESSCKSWLSSMTMDSEDGYQTCVSEDSSRGAFSRQTSTDDECFIPKEGDDFLRRSSSR
RNRSISNTSSGSMSPLWEGNLSSMFGTLPRKSRKGSVRKQLLKFIPGLHRAVEEEESRF
Target Bioclass
Other
Subcellular location
Cytoplasm
Function By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm.
Uniprot ID
O60759
Ensemble ID
ENST00000264192.8
HGNC ID
HGNC:9506

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A101D SNV: p.I42S .
FADU SNV: p.W189C .
HCT116 Deletion: p.K288RfsTer7 .
KP4 SNV: p.N307S .
LNCaP clone FGC SNV: p.R63K .
MCC26 SNV: p.H204N .
MDST8 SNV: p.S153L .
MEWO SNV: p.L213Ter .
MOLT4 SNV: p.L221F .
NCIH1703 SNV: p.S212I .
SKMEL2 SNV: p.S241F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C246(2.24)  LDD3411  [1]
IA-alkyne
 Probe Info  		C246(7.66)  LDD1704  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C246(1.42); C122(1.58)  LDD2187  [3]
 LDCM0572  Fragment10 Ramos C246(1.74)  LDD2189  [3]
 LDCM0573  Fragment11 Ramos C246(2.58); C122(0.64)  LDD2190  [3]
 LDCM0574  Fragment12 Ramos C246(1.33)  LDD2191  [3]
 LDCM0575  Fragment13 Ramos C246(0.94)  LDD2192  [3]
 LDCM0576  Fragment14 Ramos C246(1.03); C122(0.91)  LDD2193  [3]
 LDCM0579  Fragment20 Ramos C246(1.63)  LDD2194  [3]
 LDCM0580  Fragment21 Ramos C246(1.10)  LDD2195  [3]
 LDCM0582  Fragment23 Ramos C246(1.04)  LDD2196  [3]
 LDCM0578  Fragment27 Ramos C246(0.99)  LDD2197  [3]
 LDCM0586  Fragment28 Ramos C246(0.76); C122(0.54)  LDD2198  [3]
 LDCM0588  Fragment30 Ramos C246(1.54)  LDD2199  [3]
 LDCM0589  Fragment31 Ramos C246(1.08)  LDD2200  [3]
 LDCM0590  Fragment32 Ramos C246(1.99)  LDD2201  [3]
 LDCM0468  Fragment33 Ramos C246(1.17)  LDD2202  [3]
 LDCM0596  Fragment38 Ramos C246(1.09)  LDD2203  [3]
 LDCM0566  Fragment4 Ramos C246(1.06); C122(0.43)  LDD2184  [3]
 LDCM0610  Fragment52 Ramos C246(2.38)  LDD2204  [3]
 LDCM0614  Fragment56 Ramos C246(1.82)  LDD2205  [3]
 LDCM0569  Fragment7 Ramos C246(1.16); C122(0.84)  LDD2186  [3]
 LDCM0571  Fragment9 Ramos C246(2.08)  LDD2188  [3]
 LDCM0022  KB02 T cell-activated C246(7.66)  LDD1704  [2]
 LDCM0023  KB03 Ramos C246(1.02); C122(0.53)  LDD2183  [3]
 LDCM0024  KB05 RPMI-8226 C246(2.24)  LDD3411  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
Kinesin-like protein KIF9 (KIF9) Kinesin family Q9HAQ2
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytohesin-1 (CYTH1) . Q15438
Microspherule protein 1 (MCRS1) . Q96EZ8
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
3 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578