Details of the Target
General Information of Target
| Target ID | LDTP00863 | |||||
|---|---|---|---|---|---|---|
| Target Name | Lipoyl synthase, mitochondrial (LIAS) | |||||
| Gene Name | LIAS | |||||
| Gene ID | 11019 | |||||
| Synonyms |
LAS; Lipoyl synthase, mitochondrial; EC 2.8.1.8; Lipoate synthase; LS; Lip-syn; Lipoic acid synthase |
|||||
| 3D Structure | ||||||
| Sequence |
MSLRCGDAARTLGPRVFGRYFCSPVRPLSSLPDKKKELLQNGPDLQDFVSGDLADRSTWD
EYKGNLKRQKGERLRLPPWLKTEIPMGKNYNKLKNTLRNLNLHTVCEEARCPNIGECWGG GEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDASEPYNTAKAIAEWGLDYVVLTSV DRDDMPDGGAEHIAKTVSYLKERNPKILVECLTPDFRGDLKAIEKVALSGLDVYAHNVET VPELQSKVRDPRANFDQSLRVLKHAKKVQPDVISKTSIMLGLGENDEQVYATMKALREAD VDCLTLGQYMQPTRRHLKVEEYITPEKFKYWEKVGNELGFHYTASGPLVRSSYKAGEFFL KNLVAKRKTKDL |
|||||
| Target Bioclass |
Enzyme
|
|||||
| Family |
Radical SAM superfamily, Lipoyl synthase family
|
|||||
| Subcellular location |
Mitochondrion
|
|||||
| Function |
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. {|HAMAP-Rule:MF_03123}.
|
|||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C106(2.10) | LDD3314 | [1] | |
|
IA-alkyne Probe Info |
 |
N.A. | LDD0162 | [2] | |
|
Lodoacetamide azide Probe Info |
 |
N.A. | LDD0037 | [3] | |
|
NAIA_5 Probe Info |
 |
N.A. | LDD2223 | [4] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0572 | Fragment10 | Ramos | C106(1.01) | LDD2189 | [5] |
| LDCM0573 | Fragment11 | Ramos | C106(0.37) | LDD2190 | [5] |
| LDCM0576 | Fragment14 | Ramos | C106(1.51) | LDD2193 | [5] |
| LDCM0588 | Fragment30 | Ramos | C106(1.05) | LDD2199 | [5] |
| LDCM0596 | Fragment38 | Ramos | C106(0.61) | LDD2203 | [5] |
| LDCM0571 | Fragment9 | Ramos | C106(0.95) | LDD2188 | [5] |
| LDCM0022 | KB02 | ABC-1 | C106(1.91) | LDD2262 | [1] |
| LDCM0023 | KB03 | A-549 | C106(1.75) | LDD2677 | [1] |
| LDCM0024 | KB05 | IGR37 | C106(2.10) | LDD3314 | [1] |
The Interaction Atlas With This Target
References