Details of the Target

General Information of Target

Target ID LDTP00860
Target Name Synaptogyrin-3 (SYNGR3)
Gene Name SYNGR3
Gene ID 9143
Synonyms
Synaptogyrin-3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEGASFGAGRAGAALDPVSFARRPQTLLRVASWVFSIAVFGPIVNEGYVNTDSGPELRCV
FNGNAGACRFGVALGLGAFLACAAFLLLDVRFQQISSVRDRRRAVLLDLGFSGLWSFLWF
VGFCFLTNQWQRTAPGPATTQAGDAARAAIAFSFFSILSWVALTVKALQRFRLGTDMSLF
ATEQLSTGASQAYPGYPVGSGVEGTETYQSPPFTETLDTSPKGYQVPAY
Target Bioclass
Other
Family
Synaptogyrin family
Subcellular location
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Function
May play a role in regulated exocytosis. May indirectly regulate the activity of the plasma membrane dopamine transporter SLC6A3 and thereby regulate dopamine transport back from the synaptic cleft into the presynaptic terminal.
Uniprot ID
O43761
Ensemble ID
ENST00000248121.7
HGNC ID
HGNC:11501

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		2.52  LDD2182  [1]
DBIA
 Probe Info  		C59(1.01)  LDD1512  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0259  AC14 HEK-293T C59(1.01)  LDD1512  [2]
 LDCM0282  AC22 HEK-293T C59(0.99)  LDD1521  [2]
 LDCM0291  AC30 HEK-293T C59(0.98)  LDD1530  [2]
 LDCM0299  AC38 HEK-293T C59(0.99)  LDD1538  [2]
 LDCM0308  AC46 HEK-293T C59(1.02)  LDD1547  [2]
 LDCM0317  AC54 HEK-293T C59(0.99)  LDD1556  [2]
 LDCM0323  AC6 HEK-293T C59(0.99)  LDD1562  [2]
 LDCM0326  AC62 HEK-293T C59(1.04)  LDD1565  [2]
 LDCM0368  CL10 HEK-293T C59(1.10)  LDD1572  [2]
 LDCM0410  CL22 HEK-293T C59(0.96)  LDD1614  [2]
 LDCM0423  CL34 HEK-293T C59(1.10)  LDD1627  [2]
 LDCM0436  CL46 HEK-293T C59(0.92)  LDD1640  [2]
 LDCM0449  CL58 HEK-293T C59(0.97)  LDD1652  [2]
 LDCM0463  CL70 HEK-293T C59(0.96)  LDD1666  [2]
 LDCM0476  CL82 HEK-293T C59(1.03)  LDD1679  [2]
 LDCM0489  CL94 HEK-293T C59(0.99)  LDD1692  [2]
 LDCM0582  Fragment23 Ramos 0.78  LDD2196  [1]
 LDCM0578  Fragment27 Ramos 1.52  LDD2197  [1]
 LDCM0586  Fragment28 Ramos 1.73  LDD2198  [1]
 LDCM0022  KB02 Ramos 2.52  LDD2182  [1]

References

1 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402