Details of the Target

General Information of Target

Target ID LDTP00858
Target Name Synaptogyrin-1 (SYNGR1)
Gene Name SYNGR1
Gene ID 9145
Synonyms
Synaptogyrin-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEGGAYGAGKAGGAFDPYTLVRQPHTILRVVSWLFSIVVFGSIVNEGYLNSASEGEEFCI
YNRNPNACSYGVAVGVLAFLTCLLYLALDVYFPQISSVKDRKKAVLSDIGVSAFWAFLWF
VGFCYLANQWQVSKPKDNPLNEGTDAARAAIAFSFFSIFTWAGQAVLAFQRYQIGADSAL
FSQDYMDPSQDSSMPYAPYVEPTGPDPAGMGGTYQQPANTFDTEPQGYQSQGY
Target Bioclass
Other
Family
Synaptogyrin family
Subcellular location
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Function
May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation. Involved in the regulation of short-term and long-term synaptic plasticity.
Uniprot ID
O43759
Ensemble ID
ENST00000318801.8
HGNC ID
HGNC:11498

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A375 SNV: p.E142G .
IGROV1 Deletion: p.F156SfsTer82 .
IM95 SNV: p.D100G .
MOLT4 SNV: p.Q190R .
SHP77 Substitution: p.A127T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CHEMBL5175495
 Probe Info  		5.58  LDD0196  [1]
TH211
 Probe Info  		Y18(20.00)  LDD0260  [2]
TH216
 Probe Info  		Y18(20.00)  LDD0259  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
Bifunctional polynucleotide phosphatase/kinase (PNKP) DNA 3' phosphatase family Q96T60
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
Peroxisomal bifunctional enzyme (EHHADH) Enoyl-CoA hydratase/isomerase family; 3-hydroxyacyl-CoA dehydrogenase family Q08426
MYG1 exonuclease (MYG1) MYG1 family Q9HB07
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sodium-dependent organic anion transporter (SLC10A6) Bile acid:sodium symporter (BASS) family Q3KNW5
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Sorting nexin-1 (SNX1) Sorting nexin family Q13596
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Syntenin-1 (SDCBP) . O00560
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
GPCR
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adenosine receptor A2a (ADORA2A) G-protein coupled receptor 1 family P29274
G-protein coupled receptor 42 (GPR42) G-protein coupled receptor 1 family O15529
Other
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Protein FAM209A (FAM209A) FAM209 family Q5JX71
Transcription termination factor 3, mitochondrial (MTERF3) MTERF family Q96E29
Leptin receptor gene-related protein (LEPROT) OB-RGRP/VPS55 family O15243
Perilipin-3 (PLIN3) Perilipin family O60664
Reticulophagy regulator 3 (RETREG3) RETREG family Q86VR2
Transmembrane protein 45B (TMEM45B) TMEM45 family Q96B21
Fetal and adult testis-expressed transcript protein (FATE1) . Q969F0
Pleckstrin homology domain-containing family B member 2 (PLEKHB2) . Q96CS7
Transmembrane protein 80 (TMEM80) . Q96HE8

References

1 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.