Details of the Target

General Information of Target

Target ID LDTP00848
Target Name Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial (GATC)
Gene Name GATC
Gene ID 283459
Synonyms
15E1.2; Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial; Glu-AdT subunit C; EC 6.3.5.-; Protein 15E1.2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWSRLVWLGLRAPLGGRQGFTSKADPQGSGRITAAVIEHLERLALVDFGSREAVARLEKA
IAFADRLRAVDTDGVEPMESVLEDRCLYLRSDNVVEGNCADELLQNSHRVVEEYFVAPPG
NISLPKLDEQEPFPHS
Target Bioclass
Enzyme
Family
GatC family
Subcellular location
Mitochondrion
Function
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). {|HAMAP-Rule:MF_03149}.
Uniprot ID
O43716
Ensemble ID
ENST00000551765.6
HGNC ID
HGNC:25068

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
DBIA
 Probe Info  		C99(2.04)  LDD3323  [3]
IA-alkyne
 Probe Info  		C99(0.64)  LDD2182  [4]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [5]
Phosphinate-6
 Probe Info  		C99(0.00); C86(0.00)  LDD0018  [6]
Acrolein
 Probe Info  		N.A.  LDD0217  [7]
Methacrolein
 Probe Info  		N.A.  LDD0218  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0156  Aniline NCI-H1299 13.37  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [7]
 LDCM0625  F8 Ramos C99(1.29)  LDD2187  [4]
 LDCM0572  Fragment10 Ramos C99(0.45)  LDD2189  [4]
 LDCM0573  Fragment11 Ramos C99(0.24)  LDD2190  [4]
 LDCM0574  Fragment12 Ramos C99(0.66)  LDD2191  [4]
 LDCM0575  Fragment13 Ramos C99(0.87)  LDD2192  [4]
 LDCM0576  Fragment14 Ramos C99(0.87)  LDD2193  [4]
 LDCM0579  Fragment20 Ramos C99(0.73)  LDD2194  [4]
 LDCM0580  Fragment21 Ramos C99(1.17)  LDD2195  [4]
 LDCM0582  Fragment23 Ramos C99(1.34)  LDD2196  [4]
 LDCM0578  Fragment27 Ramos C99(0.91)  LDD2197  [4]
 LDCM0586  Fragment28 Ramos C99(0.61)  LDD2198  [4]
 LDCM0588  Fragment30 Ramos C99(1.01)  LDD2199  [4]
 LDCM0589  Fragment31 Ramos C99(0.82)  LDD2200  [4]
 LDCM0590  Fragment32 Ramos C99(0.40)  LDD2201  [4]
 LDCM0468  Fragment33 Ramos C99(0.57)  LDD2202  [4]
 LDCM0596  Fragment38 Ramos C99(0.97)  LDD2203  [4]
 LDCM0566  Fragment4 Ramos C99(0.95)  LDD2184  [4]
 LDCM0610  Fragment52 Ramos C99(0.92)  LDD2204  [4]
 LDCM0614  Fragment56 Ramos C99(1.18)  LDD2205  [4]
 LDCM0569  Fragment7 Ramos C99(0.66)  LDD2186  [4]
 LDCM0571  Fragment9 Ramos C99(0.59)  LDD2188  [4]
 LDCM0022  KB02 Ramos C99(0.64)  LDD2182  [4]
 LDCM0023  KB03 Ramos C99(0.82)  LDD2183  [4]
 LDCM0024  KB05 SKMEL24 C99(2.04)  LDD3323  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial (QRSL1) Amidase family Q9H0R6
Polyunsaturated fatty acid 5-lipoxygenase (ALOX5) Lipoxygenase family P09917
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cancer/testis antigen 1 (CTAG1A; CTAG1B) CTAG/PCC1 family P78358
Serine/arginine-rich splicing factor 11 (SRSF11) Splicing factor SR family Q05519
TOMM20-like protein 1 (TOMM20L) Tom20 family Q6UXN7
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.