Details of the Target

General Information of Target

Target ID LDTP00842
Target Name Sulfotransferase 1B1 (SULT1B1)
Gene Name SULT1B1
Gene ID 27284
Synonyms
ST1B2; SULT1B2; Sulfotransferase 1B1; ST1B1; EC 2.8.2.1; Sulfotransferase 1B2; Sulfotransferase family cytosolic 1B member 1; Thyroid hormone sulfotransferase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLSPKDILRKDLKLVHGYPMTCAFASNWEKIEQFHSRPDDIVIATYPKSGTTWVSEIIDM
ILNDGDIEKCKRGFITEKVPMLEMTLPGLRTSGIEQLEKNPSPRIVKTHLPTDLLPKSFW
ENNCKMIYLARNAKDVSVSYYHFDLMNNLQPFPGTWEEYLEKFLTGKVAYGSWFTHVKNW
WKKKEEHPILFLYYEDMKENPKEEIKKIIRFLEKNLNDEILDRIIHHTSFEVMKDNPLVN
YTHLPTTVMDHSKSPFMRKGTAGDWKNYFTVAQNEKFDAIYETEMSKTALQFRTEI
Target Bioclass
Enzyme
Family
Sulfotransferase 1 family
Subcellular location
Cytoplasm
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine (T3) and reverse triiodothyronine (rT3). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system.
Uniprot ID
O43704
Ensemble ID
ENST00000310613.8
HGNC ID
HGNC:17845
ChEMBL ID
CHEMBL1743294

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C22(2.45)  LDD3373  [1]
IA-alkyne
 Probe Info  		C22(6.82)  LDD1705  [2]
CY4
 Probe Info  		N.A.  LDD0247  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A2780 C22(1.55)  LDD2254  [1]
 LDCM0023  KB03 A2780 C22(1.65)  LDD2671  [1]
 LDCM0024  KB05 OCUG-1 C22(2.45)  LDD3373  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Threonine--tRNA ligase 1, cytoplasmic (TARS1) Class-II aminoacyl-tRNA synthetase family P26639
Cytochrome b-c1 complex subunit 1, mitochondrial (UQCRC1) Peptidase M16 family P31930
Sulfotransferase 2A1 (SULT2A1) Sulfotransferase 1 family Q06520
Sulfotransferase 2B1 (SULT2B1) Sulfotransferase 1 family O00204
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Syntenin-1 (SDCBP) . O00560
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Prefoldin subunit 3 (VBP1) Prefoldin subunit alpha family P61758
Protection of telomeres protein 1 (POT1) Telombin family Q9NUX5

The Drug(s) Related To This Target

Approved
Click To Hide/Show 7 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Apomorphine Small molecular drug DB00714
Ibrexafungerp Small molecular drug DB12471
Methyldopa Small molecular drug DB00968
Pindolol Small molecular drug DB00960
Ritodrine Small molecular drug DB00867
Terbutaline Small molecular drug DB00871
Thyroid Porcine . DB09100
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Adenosine 3'5'-diphosphate Small molecular drug DB01812
Curcumin Sulfate . DB14635

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.