Details of the Target

General Information of Target

Target ID LDTP00799
Target Name Epsilon-sarcoglycan (SGCE)
Gene Name SGCE
Gene ID 8910
Synonyms
ESG; Epsilon-sarcoglycan; Epsilon-SG
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQLPRWWELGDPCAWTGQGRGTRRMSPATTGTFLLTVYSIFSKVHSDRNVYPSAGVLFVH
VLEREYFKGEFPPYPKPGEISNDPITFNTNLMGYPDRPGWLRYIQRTPYSDGVLYGSPTA
ENVGKPTIIEITAYNRRTFETARHNLIINIMSAEDFPLPYQAEFFIKNMNVEEMLASEVL
GDFLGAVKNVWQPERLNAINITSALDRGGRVPLPINDLKEGVYVMVGADVPFSSCLREVE
NPQNQLRCSQEMEPVITCDKKFRTQFYIDWCKISLVDKTKQVSTYQEVIRGEGILPDGGE
YKPPSDSLKSRDYYTDFLITLAVPSAVALVLFLILAYIMCCRREGVEKRNMQTPDIQLVH
HSAIQKSTKELRDMSKNREIAWPLSTLPVFHPVTGEIIPPLHTDNYDSTNMPLMQTQQNL
PHQTQIPQQQTTGKWYP
Target Bioclass
Other
Family
Sarcoglycan alpha/epsilon family
Subcellular location
Cell membrane, sarcolemma
Function Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
Uniprot ID
O43556
Ensemble ID
ENST00000445866.7
HGNC ID
HGNC:10808

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
LNCaP clone FGC SNV: p.D259N .
MEWO SNV: p.P231S .
NCIH1299 SNV: p.L331V .
OZ SNV: p.T403R .
RL SNV: p.I150K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C235(1.32)  LDD1508  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C235(1.32)  LDD1508  [1]
 LDCM0237  AC12 HEK-293T C235(0.90)  LDD1510  [1]
 LDCM0277  AC18 HEK-293T C235(0.89)  LDD1516  [1]
 LDCM0279  AC2 HEK-293T C235(0.78)  LDD1518  [1]
 LDCM0280  AC20 HEK-293T C235(0.87)  LDD1519  [1]
 LDCM0286  AC26 HEK-293T C235(0.76)  LDD1525  [1]
 LDCM0288  AC28 HEK-293T C235(1.09)  LDD1527  [1]
 LDCM0295  AC34 HEK-293T C235(1.00)  LDD1534  [1]
 LDCM0297  AC36 HEK-293T C235(1.02)  LDD1536  [1]
 LDCM0301  AC4 HEK-293T C235(1.04)  LDD1540  [1]
 LDCM0304  AC42 HEK-293T C235(0.91)  LDD1543  [1]
 LDCM0306  AC44 HEK-293T C235(0.92)  LDD1545  [1]
 LDCM0313  AC50 HEK-293T C235(1.09)  LDD1552  [1]
 LDCM0315  AC52 HEK-293T C235(0.98)  LDD1554  [1]
 LDCM0321  AC58 HEK-293T C235(1.09)  LDD1560  [1]
 LDCM0324  AC60 HEK-293T C235(1.12)  LDD1563  [1]
 LDCM0405  CL18 HEK-293T C235(1.82)  LDD1609  [1]
 LDCM0408  CL20 HEK-293T C235(1.07)  LDD1612  [1]
 LDCM0419  CL30 HEK-293T C235(1.01)  LDD1623  [1]
 LDCM0421  CL32 HEK-293T C235(1.14)  LDD1625  [1]
 LDCM0432  CL42 HEK-293T C235(1.26)  LDD1636  [1]
 LDCM0434  CL44 HEK-293T C235(0.80)  LDD1638  [1]
 LDCM0445  CL54 HEK-293T C235(1.07)  LDD1648  [1]
 LDCM0447  CL56 HEK-293T C235(1.01)  LDD1650  [1]
 LDCM0451  CL6 HEK-293T C235(1.13)  LDD1654  [1]
 LDCM0458  CL66 HEK-293T C235(1.19)  LDD1661  [1]
 LDCM0460  CL68 HEK-293T C235(0.96)  LDD1663  [1]
 LDCM0471  CL78 HEK-293T C235(1.28)  LDD1674  [1]
 LDCM0473  CL8 HEK-293T C235(0.78)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C235(0.96)  LDD1677  [1]
 LDCM0485  CL90 HEK-293T C235(1.15)  LDD1688  [1]
 LDCM0487  CL92 HEK-293T C235(0.94)  LDD1690  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402