Details of the Target

General Information of Target

Target ID LDTP00713
Target Name Kallikrein-10 (KLK10)
Gene Name KLK10
Gene ID 5655
Synonyms
NES1; PRSSL1; Kallikrein-10; EC 3.4.21.-; Normal epithelial cell-specific 1; Protease serine-like 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRAPHLHLSAASGARALAKLLPLLMAQLWAAEAALLPQNDTRLDPEAYGSPCARGSQPWQ
VSLFNGLSFHCAGVLVDQSWVLTAAHCGNKPLWARVGDDHLLLLQGEQLRRTTRSVVHPK
YHQGSGPILPRRTDEHDLMLLKLARPVVLGPRVRALQLPYRCAQPGDQCQVAGWGTTAAR
RVKYNKGLTCSSITILSPKECEVFYPGVVTNNMICAGLDRGQDPCQSDSGGPLVCDETLQ
GILSWGVYPCGSAQHPAVYTQICKYMSWINKVIRSN
Target Bioclass
Enzyme
Family
Peptidase S1 family, Kallikrein subfamily
Subcellular location
Secreted
Function Has a tumor-suppressor role for NES1 in breast and prostate cancer.
Uniprot ID
O43240
Ensemble ID
ENST00000309958.7
HGNC ID
HGNC:6358

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C190(1.77)  LDD3373  [1]
MPP-AC
 Probe Info  		N.A.  LDD0428  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 COLO 320 C190(1.37)  LDD2303  [1]
 LDCM0023  KB03 COLO 320 C190(1.17)  LDD2720  [1]
 LDCM0024  KB05 OCUG-1 C190(1.77)  LDD3373  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.