Details of the Target
General Information of Target
| Target ID | LDTP00638 | |||||
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| Target Name | ATP-binding cassette sub-family C member 3 (ABCC3) |
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| Gene Name | ABCC3 | |||||
| Gene ID | 8714 | |||||
| Synonyms |
CMOAT2; MLP2; MRP3; ATP-binding cassette sub-family C member 3; EC 7.6.2.-; EC 7.6.2.2; EC 7.6.2.3; Canalicular multispecific organic anion transporter 2; Multi-specific organic anion transporter D; MOAT-D; Multidrug resistance-associated protein 3
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| 3D Structure | ||||||
| Sequence |
MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC
RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFAL VLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDL WSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFL KALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCS MMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRF MDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQ MKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWM CSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLK RIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVV GPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRY QQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSA VDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQ RNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQ KQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFW DYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGI LQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVD EVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLE SVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVE FVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERV KEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVG IVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTL RMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARAL LRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGV VAEFDSPANLIAARGIFYGMARDAGLA |
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| Target Bioclass |
Enzyme
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| Family |
ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily
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| Subcellular location |
Basolateral cell membrane
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| Function |
ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Can confer resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| CAL27 | SNV: p.S91F | DBIA Probe Info | |||
| CMK | SNV: p.Q614H | DBIA Probe Info | |||
| HCT15 | SNV: p.V806M | DBIA Probe Info | |||
| HEC1 | SNV: p.C82Y | . | |||
| HEC1B | SNV: p.C82Y | . | |||
| JHH7 | SNV: p.N716Y | . | |||
| JURKAT | Deletion: p.Q614RfsTer34 | . | |||
| KYSE510 | SNV: p.E126Q | DBIA Probe Info | |||
| LOXIMVI | SNV: p.D791N | DBIA Probe Info | |||
| LS180 | SNV: p.P1056S | DBIA Probe Info | |||
| MEWO | SNV: p.L1484P | . | |||
| NCIH2286 | SNV: p.Q477H | DBIA Probe Info | |||
| NCIH716 | SNV: p.G1378V | . | |||
| ONS76 | SNV: p.T628S | DBIA Probe Info | |||
| RKO | SNV: p.S7P | DBIA Probe Info | |||
| TOV21G | SNV: p.W995R | DBIA Probe Info | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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IPM Probe Info |
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C665(0.00); C1435(0.00); C1071(0.00) | LDD0241 | [1] | |
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DBIA Probe Info |
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C716(1.90); C1486(2.82) | LDD3310 | [2] | |
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BTD Probe Info |
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C1071(4.49) | LDD2097 | [3] | |
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WYneN Probe Info |
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N.A. | LDD0021 | [4] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0519 | 1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one | MDA-MB-231 | C1071(1.06) | LDD2112 | [3] |
| LDCM0022 | KB02 | 22RV1 | C1486(1.89) | LDD2243 | [2] |
| LDCM0023 | KB03 | 22RV1 | C1486(1.33) | LDD2660 | [2] |
| LDCM0024 | KB05 | COLO792 | C716(1.90); C1486(2.82) | LDD3310 | [2] |
| LDCM0504 | Nucleophilic fragment 15a | MDA-MB-231 | C1071(4.49) | LDD2097 | [3] |
| LDCM0507 | Nucleophilic fragment 16b | MDA-MB-231 | C1071(0.84) | LDD2100 | [3] |
| LDCM0513 | Nucleophilic fragment 19b | MDA-MB-231 | C1071(0.79) | LDD2106 | [3] |
| LDCM0525 | Nucleophilic fragment 25b | MDA-MB-231 | C1071(0.97) | LDD2118 | [3] |
| LDCM0541 | Nucleophilic fragment 36 | MDA-MB-231 | C1071(0.92) | LDD2134 | [3] |
| LDCM0542 | Nucleophilic fragment 37 | MDA-MB-231 | C1435(1.01) | LDD2135 | [3] |
| LDCM0547 | Nucleophilic fragment 41 | MDA-MB-231 | C1071(0.75) | LDD2141 | [3] |
| LDCM0554 | Nucleophilic fragment 7a | MDA-MB-231 | C1071(0.34) | LDD2148 | [3] |
| LDCM0555 | Nucleophilic fragment 7b | MDA-MB-231 | C1071(0.67) | LDD2149 | [3] |
The Interaction Atlas With This Target
The Drug(s) Related To This Target
Approved
Investigative
| Drug Name | Drug Type | External ID | |||
|---|---|---|---|---|---|
| Dovitinib | . | DB05928 | |||
References