General Information of Target

Target ID LDTP00626
Target Name Transcription factor YY2 (YY2)
Gene Name YY2
Gene ID 404281
Synonyms
ZNF631; Transcription factor YY2; Yin and yang 2; YY-2; Zinc finger protein 631
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASNEDFSITQDLEIPADIVELHDINVEPLPMEDIPTESVQYEDVDGNWIYGGHNHPPLM
VLQPLFTNTGYGDHDQEMLMLQTQEEVVGYCDSDNQLGNDLEDQLALPDSIEDEHFQMTL
ASLSASAASTSTSTQSRSKKPSKKPSGKSATSTEANPAGSSSSLGTRKWEQKQMQVKTLE
GEFSVTMWSPNDNNDQGAVGEGQAENPPDYSEYLKGKKLPPGGLPGIDLSDPKQLAEFTK
VKPKRSKGEPPKTVPCSYSGCEKMFRDYAAMRKHLHIHGPRVHVCAECGKAFLESSKLRR
HQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHLRIHTGDKPFVCPFDVCNRKFAQSTNLKT
HILTHVKTKNNP
Target Bioclass
Transcription factor
Family
YY transcription factor family
Subcellular location
Nucleus
Function Functions as a multifunctional transcription factor that may exhibit positive and negative control on a large number of genes. May antagonize YY1 and function in development and differentiation.
Uniprot ID
O15391
Ensemble ID
ENST00000429584.3
HGNC ID
HGNC:31684

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info 
C288(0.88)  LDD2129  [1]
Acrolein
 Probe Info 
N.A.  LDD0221  [2]
NAIA_5
 Probe Info 
C318(0.00); C313(0.00)  LDD2223  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0107  IAA HeLa N.A.  LDD0221  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C288(0.88)  LDD2129  [1]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C285(0.28)  LDD2147  [1]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264