Details of the Target

General Information of Target

Target ID LDTP00588
Target Name Chloride intracellular channel protein 2 (CLIC2)
Gene Name CLIC2
Gene ID 1193
Synonyms
Chloride intracellular channel protein 2; XAP121
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGLRPGTQVDPEIELFVKAGSDGESIGNCPFCQRLFMILWLKGVKFNVTTVDMTRKPEE
LKDLAPGTNPPFLVYNKELKTDFIKIEEFLEQTLAPPRYPHLSPKYKESFDVGCNLFAKF
SAYIKNTQKEANKNFEKSLLKEFKRLDDYLNTPLLDEIDPDSAEEPPVSRRLFLDGDQLT
LADCSLLPKLNIIKVAAKKYRDFDIPAEFSGVWRYLHNAYAREEFTHTCPEDKEIENTYA
NVAKQKS
Target Bioclass
Transporter and channel
Family
Chloride channel CLIC family
Subcellular location
Cytoplasm
Function
Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx.
Uniprot ID
O15247
Ensemble ID
ENST00000369449.7
HGNC ID
HGNC:2063

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C33(1.36)  LDD2229  [1]
IA-alkyne
 Probe Info  		C30(1.11); C114(1.02); C229(0.93)  LDD0304  [2]
DBIA
 Probe Info  		C114(1.39)  LDD3310  [3]
HHS-465
 Probe Info  		Y123(0.52)  LDD2237  [4]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe3
 Probe Info  		10.26  LDD0465  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A673 C114(1.69)  LDD2261  [3]
 LDCM0023  KB03 CC-SW-1 C114(1.94)  LDD2716  [3]
 LDCM0024  KB05 COLO792 C114(1.39)  LDD3310  [3]
 LDCM0131  RA190 MM1.R C30(1.11); C114(1.02); C229(0.93)  LDD0304  [2]

References

1 A quantitative thiol reactivity profiling platform to analyze redox and electrophile reactive cysteine proteomes. Nat Protoc. 2020 Sep;15(9):2891-2919. doi: 10.1038/s41596-020-0352-2. Epub 2020 Jul 20.
Mass spectrometry data entry: PXD016048
2 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
5 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.