Details of the Target
General Information of Target
| Target ID | LDTP00174 | |||||
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| Target Name | Aldo-keto reductase family 1 member B15 (AKR1B15) | |||||
| Gene Name | AKR1B15 | |||||
| Gene ID | 441282 | |||||
| Synonyms |
Aldo-keto reductase family 1 member B15; EC 1.1.1.-; EC 1.1.1.300; EC 1.1.1.54; Estradiol 17-beta-dehydrogenase AKR1B15; Farnesol dehydrogenase; EC 1.1.1.216; Testosterone 17beta-dehydrogenase; EC 1.1.1.64
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| 3D Structure | ||||||
| Sequence |
MATFVELSTKAKMPIVGLGTWRSLLGKVKEAVKVAIDAEYRHIDCAYFYENQHEVGEAIQ
EKIQEKAVMREDLFIVSKVWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKTGD DFFPKDDKGNMISGKGTFLDAWEAMEELVDEGLVKALGVSNFNHFQIERLLNKPGLKYKP VTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAK HKKTTAQVLIRFHIQRNVTVIPKSMTPAHIVENIQVFDFKLSDEEMATILSFNRNWRAFD FKEFSHLEDFPFDAEY |
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| Target Bioclass |
Enzyme
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| Family |
Aldo/keto reductase family
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| Subcellular location |
Cytoplasm, cytosol; Mitochondrion
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| Function |
[Isoform 1]: Catalyzes the NADPH-dependent reduction of a variety of carbonyl substrates, like aromatic aldehydes, alkenals, ketones and alpha-dicarbonyl compounds. In addition, catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. Displays strong enzymatic activity toward all-trans-retinal and 9-cis-retinal. May play a physiological role in retinoid metabolism.; [Isoform 2]: No oxidoreductase activity observed with the tested substrates.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
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Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
 |
C215(1.67) | LDD3319 | [1] | |
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BTD Probe Info |
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C200(0.96); C187(1.02) | LDD2107 | [2] | |
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IA-alkyne Probe Info |
 |
N.A. | LDD0036 | [3] | |
PAL-AfBPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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STS-2 Probe Info |
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N.A. | LDD0139 | [4] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0022 | KB02 | A498 | C228(1.25); C215(1.61) | LDD2259 | [1] |
| LDCM0023 | KB03 | 786-O | C228(1.61) | LDD2664 | [1] |
| LDCM0024 | KB05 | MEWO | C215(1.67) | LDD3319 | [1] |
| LDCM0514 | Nucleophilic fragment 20a | MDA-MB-231 | C200(0.96); C187(1.02) | LDD2107 | [2] |
| LDCM0544 | Nucleophilic fragment 39 | MDA-MB-231 | C200(0.61) | LDD2137 | [2] |
| LDCM0546 | Nucleophilic fragment 40 | MDA-MB-231 | C187(0.76) | LDD2140 | [2] |
| LDCM0551 | Nucleophilic fragment 5b | MDA-MB-231 | C187(0.69) | LDD2145 | [2] |
The Interaction Atlas With This Target
References