Details of the Target

General Information of Target

Target ID LDTP00060
Target Name Protein FAM221A (FAM221A)
Gene Name FAM221A
Gene ID 340277
Synonyms
C7orf46; Protein FAM221A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MERLTLPLGGAAAVDEYLEYRRIVGEDDGGKLFTPEEYEEYKRKVLPLRLQNRLFVSWRS
PTGMDCKLVGPETLCFCTHRYKQHKTDLEAIPQQCPIDLPCQVTGCQCRAYLYVPLNGSQ
PIRCRCKHFADQHSAAPGFTCNTCSKCSGFHSCFTCACGQPAYAHDTVVETKQERLAQEK
PVGQDIPYAAMGGLTGFSSLAEGYMRLDDSGIGVPSVEFLESPITAVDSPFLKAFQASSS
SSPETLTDVGTSSQVSSLRRPEEDDMAFFERRYQERMKMEKAAKWKGKAPLPSATKPS
Target Bioclass
Other
Family
FAM221 family
Uniprot ID
A4D161
Ensemble ID
ENST00000344962.9
HGNC ID
HGNC:27977

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.C108Y .
CAL148 SNV: p.S256F .
CCLP1 SNV: p.S256F .
MCC26 SNV: p.Q236Ter .
SKMEL3 SNV: p.P187S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C95(1.42)  LDD2157  [1]
DBIA
 Probe Info  		C66(1.75)  LDD3344  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0270  AC15 HEK-293T C95(1.02)  LDD1513  [3]
 LDCM0283  AC23 HEK-293T C95(1.04)  LDD1522  [3]
 LDCM0292  AC31 HEK-293T C95(1.02)  LDD1531  [3]
 LDCM0300  AC39 HEK-293T C95(1.11)  LDD1539  [3]
 LDCM0309  AC47 HEK-293T C95(1.15)  LDD1548  [3]
 LDCM0318  AC55 HEK-293T C95(1.16)  LDD1557  [3]
 LDCM0327  AC63 HEK-293T C95(1.04)  LDD1566  [3]
 LDCM0334  AC7 HEK-293T C95(1.17)  LDD1568  [3]
 LDCM0379  CL11 HEK-293T C95(1.05)  LDD1583  [3]
 LDCM0411  CL23 HEK-293T C95(0.95)  LDD1615  [3]
 LDCM0424  CL35 HEK-293T C95(1.14)  LDD1628  [3]
 LDCM0437  CL47 HEK-293T C95(1.09)  LDD1641  [3]
 LDCM0450  CL59 HEK-293T C95(1.05)  LDD1653  [3]
 LDCM0464  CL71 HEK-293T C95(1.10)  LDD1667  [3]
 LDCM0477  CL83 HEK-293T C95(1.03)  LDD1680  [3]
 LDCM0490  CL95 HEK-293T C95(0.99)  LDD1693  [3]
 LDCM0022  KB02 HEK-293T C95(1.09)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C95(1.12)  LDD1497  [3]
 LDCM0024  KB05 NCI-H146 C66(1.75)  LDD3344  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cysteine-rich DPF motif domain-containing protein 1 (CDPF1) CDPF1 family Q6NVV7
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Keratin-associated protein 1-1 (KRTAP1-1) KRTAP type 1 family Q07627
Keratin-associated protein 4-11 (KRTAP4-11) KRTAP type 4 family Q9BYQ6
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
Prefoldin subunit 5 (PFDN5) Prefoldin subunit alpha family Q99471
Small ubiquitin-related modifier 3 (SUMO3) Ubiquitin family P55854
Keratin-associated protein 21-2 (KRTAP21-2) . Q3LI59
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Mol Syst Biol. 2021 Feb;17(2):e9840. doi: 10.15252/msb.20209840.
Mass spectrometry data entry: PXD022151
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402