Details of the Target

General Information of Target

Target ID LDTP20075
Target Name Protein SPMIP1 (SPMIP1)
Gene Name SPMIP1
Gene ID 100130705
Synonyms
ATP6V1FNB; Protein SPMIP1; ATP6V1F neighbor gene protein; Protein ATP6V1FNB; Sperm-associated microtubule inner protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGLKGAWCFPWCGCRRQRGTERGAGLSPAAPPDPSPAIAPTMAEGGVPSPGPGAYFSRKA
RLSFRHQLHDIASANDSTI
Target Bioclass
Other
Uniprot ID
A0A1B0GUX0
Ensemble ID
ENST00000609480.4
HGNC ID
HGNC:52392

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C367(5.27)  LDD3310  [1]
NAIA_5
 Probe Info  		N.A.  LDD2225  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 CHL1 C367(3.61)  LDD2475  [1]
 LDCM0023  KB03 COLO792 C367(9.42)  LDD2893  [1]
 LDCM0024  KB05 COLO792 C367(5.27)  LDD3310  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264