General Information of Target

Target ID LDTP20020
Target Name SS18-like protein 2 (SS18L2)
Gene Name SS18L2
Gene ID 51188
Synonyms
SS18-like protein 2; SYT homolog 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRQRGQEHLPTSVKSEPRACNNPTVAENRRVPSGLAAVIRNLTALWNPSLGVSERRGGDW
EPSRIPRLWARVGWIQLPG
Target Bioclass
Other
Family
SS18 family
Uniprot ID
Q9UHA2
Ensemble ID
ENST00000011691.6
HGNC ID
HGNC:15593

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C34(3.36)  LDD3352  [1]
TFBX
 Probe Info 
N.A.  LDD0027  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A101D C34(1.29)  LDD2250  [1]
 LDCM0023  KB03 A101D C34(1.42)  LDD2667  [1]
 LDCM0024  KB05 NCI-H1975 C34(3.36)  LDD3352  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ER membrane protein complex subunit 2 (EMC2) EMC2 family Q15006
Transmembrane protein 17 (TMEM17) TMEM17 family Q86X19
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 (GNG3) G protein gamma family P63215
Ly6/PLAUR domain-containing protein 6 (LYPD6) . Q86Y78

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255